通过氢酰化作用对环丙烯进行对映选择性去对称化。
Enantioselective desymmetrization of cyclopropenes by hydroacylation.
机构信息
Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada.
出版信息
J Am Chem Soc. 2010 Nov 24;132(46):16354-5. doi: 10.1021/ja107738a. Epub 2010 Oct 28.
PMID:21028819
Abstract
We report an enantioselective desymmetrization of cyclopropenes by intermolecular Rh-catalyzed hydroacylation. Cyclopropylketones, bearing quaternary stereocenters, are produced with diastereocontrol (up to >20:1) and excellent enantiomeric excess (up to >99 ee).
摘要
我们报告了通过 Rh 催化的分子间氢酰化反应对环丙烯进行对映选择性去对称化。带有季立体中心的环丙基酮以非对映选择性控制（高达 >20:1）和优异的对映体过量（高达 >99ee）生成。
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