Bhushan Kumar R, Misra Preeti, Liu Fangbing, Mathur Sanjeev, Lenkinski Robert E, Frangioni John V
Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
J Am Chem Soc. 2008 Dec 31;130(52):17648-9. doi: 10.1021/ja807099s.
Efficient chemical synthesis of a trifunctional, hydroxyapatite-binding molecule, which provides simultaneous in vivo imaging by NIR fluorescence and SPECT/CT has been described. Quantitation by SPECT provides the "gold standard" by which NIR fluorescence tomography of breast cancer microcalcifications can now be compared and optimized.
已描述了一种三功能羟基磷灰石结合分子的高效化学合成方法，该分子可通过近红外荧光和SPECT/CT进行体内同步成像。SPECT定量提供了“金标准”，据此现在可以对乳腺癌微钙化的近红外荧光断层扫描进行比较和优化。
