Cain Robert J, Ridley Anne J
Randall Division of Cell and Molecular Biophysics, School of Biomedical and Health Sciences, King's College London, Guy's Campus, London SE1 1UL, U.K.
Biol Cell. 2009 Jan;101(1):13-29. doi: 10.1042/BC20080079.
Cell migration is essential for many biological processes in animals and is a complex highly co-ordinated process that involves cell polarization, actin-driven protrusion and formation and turnover of cell adhesions. The PI3K (phosphoinositide 3-kinase) family of lipid kinases regulate cell migration in many different cell types, both through direct binding of proteins to their lipid products and indirectly through crosstalk with other pathways, such as Rho GTPase signalling. Emerging evidence suggests that the involvement of PI3Ks at different stages of migration varies even within one cell type, and is dependent on the combination of external stimuli, as well as on the signalling status of the cell. In addition, it appears that different PI3K isoforms have distinct roles in cell polarization and migration. This review describes how PI3K signalling is regulated by pro-migratory stimuli, and the diverse ways in which PI3K-mediated signal transduction contributes to different aspects of cell migration.
细胞迁移对于动物体内的许多生物学过程至关重要，是一个复杂的高度协调的过程，涉及细胞极化、肌动蛋白驱动的突起以及细胞黏附的形成和周转。磷脂酰肌醇3激酶（PI3K）家族的脂质激酶通过蛋白质与脂质产物的直接结合以及与其他信号通路（如Rho GTPase信号通路）的间接串扰，在许多不同类型的细胞中调节细胞迁移。新出现的证据表明，即使在同一细胞类型中，PI3K在迁移不同阶段的参与情况也有所不同，这取决于外部刺激的组合以及细胞的信号状态。此外，不同的PI3K同工型在细胞极化和迁移中似乎具有不同的作用。本综述描述了PI3K信号如何由促迁移刺激调节，以及PI3K介导的信号转导以多种方式促进细胞迁移的不同方面。
