Lee Jun Sig, Lee Jong-Soup, Park Ul-Jae, Son Kwang-Jae, Han Hyon-Soo
Korea Atomic Energy Research Institute, 1045 Daeduk-daero, Yuseong-gu, Daejeon 305-353, Republic of Korea.
Appl Radiat Isot. 2009 Jul-Aug;67(7-8):1162-6. doi: 10.1016/j.apradiso.2009.02.062. Epub 2009 Feb 25.
A synthetic alumina functionalized with a sulfate moiety has been developed as the column material of (99)Mo/(99m)Tc and (188)W/(188)Re generators. This material is synthesized by a sol-gel processing. In order to characterize the adsorbent for the (188)W/(188)Re separation, both batch and column contact experiments were conducted. As a result of the experiments, it is found that the maximum capacity of the adsorbent for tungsten is higher than 450mg/g. Hence it is possible to produce approximately 3Ci (188)W/(188)Re generator with only 1g of the adsorbent from (188)W solutions supplied from ORNL, USA or RIAR, Russia. A demonstration study was conducted to show the performance of an (188)W/(188)Re generator column. In this study, 1Ci of (188)W purchased from RIAR, Russia, is loaded on a 0.9cm ID column packed with 0.7g of the adsorbent. Elution of (188)Re is performed every 4-7 days by using the saline solution for more than three months. Nearly 100% of tungsten is loaded by passing 5ml of the (188)W solution (pH=8) through the dry packed column at a 1ml/min flow rate. Elution efficiency of (188)Re is 70-90% by using 5ml of the saline solution. The ratio of (188)W/(188)Re in the eluted solution is 0.002-0.003%. When a Sep-Pak containing 0.26g of acid alumina is installed as a tandem column, the ratio is decreased to less than 10(-3)%. Thin layer chromatography for the eluted (188)Re solution shows 100% radiochemical purity. Also, alumina content in the eluted solution shows less than 10ppm. Through this study, the performance of this adsorbent was successfully demonstrated. By using the developed adsorbent, minimization of the generator column and consequently the volume of eluant could be possible while maintaining the quality of (188)Re just as much as that available in the market.
一种用硫酸根部分官能化的合成氧化铝已被开发用作（99）钼/（99m）锝和（188）钨/（188）铼发生器的柱材料。这种材料通过溶胶 - 凝胶工艺合成。为了表征用于（188）钨/（188）铼分离的吸附剂，进行了批量和柱接触实验。实验结果表明，该吸附剂对钨的最大容量高于450mg/g。因此，仅用1g吸附剂就有可能从美国橡树岭国家实验室（ORNL）或俄罗斯全俄实验物理科学研究所（RIAR）提供的（188）钨溶液中生产出约3居里的（188）钨/（188）铼发生器。进行了一项示范研究以展示（188）钨/（188）铼发生器柱的性能。在这项研究中，从俄罗斯RIAR购买的1居里（188）钨被加载到一个内径为0.9cm、装有0.7g吸附剂的柱中。使用盐溶液每4 - 7天进行一次（188）铼的洗脱，持续三个多月。通过以1ml/分钟的流速使5ml（188）钨溶液（pH = 8）通过干填充柱，几乎100%的钨被加载。使用5ml盐溶液时，（188）铼的洗脱效率为70 - 90%。洗脱液中（188）钨/（188）铼的比例为0.002 - 0.003%。当安装一个含有0.26g酸性氧化铝的Sep - Pak作为串联柱时，该比例降至小于10^(-3)%。对洗脱的（188）铼溶液进行薄层色谱分析显示放射化学纯度为100%。此外，洗脱液中的氧化铝含量显示小于10ppm。通过这项研究，该吸附剂的性能得到了成功展示。通过使用所开发的吸附剂，在保持市场上现有（188）铼质量的同时，有可能使发生器柱最小化，从而使洗脱剂体积最小化。
