亨廷顿病患者脑脊液中神经丝三联蛋白轻链亚基水平
Levels of the light subunit of neurofilament triplet protein in cerebrospinal fluid in Huntington's disease.
作者信息
Constantinescu Radu, Romer Megan, Oakes David, Rosengren Lars, Kieburtz Karl
机构信息
Department of Neurology, Sahlgrenska University Hospital, 413 45 Göteborg, Sweden.
出版信息
Parkinsonism Relat Disord. 2009 Mar;15(3):245-8. doi: 10.1016/j.parkreldis.2008.05.012. Epub 2008 Dec 4.
BACKGROUND
Neurofilaments are major structural elements of neuronal cells. The light subunit of neurofilament triplet protein (NFL) has been shown to be increased in several neurological diseases (e.g. vascular, infectious, neurodegenerative), indicating axonal damage.
METHODS
In this study we analyzed the NFL levels in all (N=35) available cerebrospinal fluid (CSF) samples from a clinical trial in Huntington's disease (HD) and compared them to age and gender matched controls.
RESULTS
The CSF-NFL levels were significantly higher in HD subjects compared with age and genders matched controls, and were correlated with scores on the Unified Huntington's Disease Rating Scale Total Functional Capacity assessment. The potential of CSF-NFL levels as a disease activity marker in HD needs to be further investigated.
背景
神经丝是神经元细胞的主要结构成分。神经丝三联体蛋白（NFL）的轻链亚基在几种神经系统疾病（如血管性、感染性、神经退行性疾病）中已被证明有所增加，提示轴突损伤。
方法
在本研究中，我们分析了一项亨廷顿舞蹈病（HD）临床试验中所有（N = 35）可用脑脊液（CSF）样本中的NFL水平，并将其与年龄和性别匹配的对照组进行比较。
结果
与年龄和性别匹配的对照组相比，HD受试者的脑脊液NFL水平显著更高，且与统一亨廷顿舞蹈病评定量表总功能能力评估得分相关。脑脊液NFL水平作为HD疾病活动标志物的潜力需要进一步研究。
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