Bosso J V, Aiken M J, Simon R A
Division of Allergy and Immunology, Scripps Clinic and Research Foundation, La Jolla, CA 92037.
Allergy Proc. 1991 Mar-Apr;12(2):113-6. doi: 10.2500/108854191779011828.
Seminal fluid hypersensitivity usually is characterized by postcoital vulvovaginal itching, swelling, redness, with or without systemic signs and symptoms. Efforts to manage this condition have either met with poor patient acceptance or have not been uniformly successful. We describe a 23-year-old atopic woman with documented IgE-mediated local and cutaneous hypersensitivity to SF. Using a controlled, single-blind challenge method, pretreatment with intravaginal 4% cromolyn sodium in a water-based cream completely blocked both local and cutaneous immediate hypersensitivity reactions to SF in this highly sensitive patient. We believe this may represent an alternative and more desirable method of preventive management in such patients.
精液过敏通常表现为性交后外阴阴道瘙痒、肿胀、发红，伴有或不伴有全身症状和体征。治疗这种疾病的努力要么患者接受度不佳，要么并非都能成功。我们描述了一名23岁的特应性女性，有记录显示其对精液存在IgE介导的局部和皮肤过敏反应。通过一种对照、单盲激发方法，在一名高敏患者中，使用水基乳膏中的4%色甘酸钠进行阴道预处理，完全阻断了对精液的局部和皮肤速发型过敏反应。我们认为这可能为此类患者提供了一种替代的、更理想的预防性治疗方法。
