Burks A W, Sampson H A
University of Arkansas, Fayetteville.
J Allergy Clin Immunol. 1988 Feb;81(2):417-23. doi: 10.1016/0091-6749(88)90910-4.
Ten children with challenge-proven egg hypersensitivity and atopic dermatitis were enrolled in a double-blind crossover trial of oral cromolyn sodium. After receiving up to 40 mg/kg/day of cromolyn or placebo for 1 week, patients underwent double-blind placebo-controlled oral food challenges. In the eight subjects who reacted to the food challenge, there was no significant difference in the amount of food allergen eliciting the positive response, the timing of onset until first subjective or objective symptoms developed, symptoms provoked, or the duration of the symptoms in either phase of the study. This study demonstrates no benefit in the treatment of children with atopic dermatitis and food hypersensitivity with oral cromolyn sodium.
十名经激发试验证实对鸡蛋过敏且患有特应性皮炎的儿童参加了口服色甘酸钠的双盲交叉试验。在接受高达40毫克/千克/天的色甘酸钠或安慰剂治疗1周后，患者接受双盲安慰剂对照的口服食物激发试验。在对食物激发试验有反应的八名受试者中，引起阳性反应的食物过敏原量、从开始到出现首个主观或客观症状的发作时间、诱发的症状或研究任一阶段症状的持续时间均无显著差异。这项研究表明，口服色甘酸钠治疗患有特应性皮炎和食物过敏的儿童并无益处。
