McLaren Donald G, Kosmatka Kristopher J, Oakes Terrance R, Kroenke Christopher D, Kohama Steven G, Matochik John A, Ingram Don K, Johnson Sterling C
Geriatric Research Education and Clinical Center, Wm. S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA.
Neuroimage. 2009 Mar 1;45(1):52-9. doi: 10.1016/j.neuroimage.2008.10.058. Epub 2008 Nov 14.
Magnetic resonance imaging (MRI) studies of non-human primates are becoming increasingly common; however, the well-developed voxel-based methodologies used in human studies are not readily applied to non-human primates. In the present study, we create a population-average MRI-based atlas collection for the rhesus macaque (Macaca mulatta) that can be used with common brain mapping packages such as SPM or FSL. In addition to creating a publicly available T1-weighted atlas (http://www.brainmap.wisc.edu/monkey.html), probabilistic tissue classification maps and T2-weighted atlases were also created. Theses atlases are aligned to the MRI volume from the Saleem, K.S. and Logothetis, N.K. (2006) atlas providing an explicit link to histological sections. Additionally, we have created a transform to integrate these atlases with the F99 surface-based atlas in CARET. It is anticipated that these tools will help facilitate voxel-based imaging methodologies in non-human primate species, which in turn may increase our understanding of brain function, development, and evolution.
对非人类灵长类动物的磁共振成像（MRI）研究正变得越来越普遍；然而，人类研究中使用的成熟的基于体素的方法并不容易应用于非人类灵长类动物。在本研究中，我们为恒河猴（猕猴）创建了一个基于群体平均MRI的图谱集，可与诸如SPM或FSL等常见的脑图谱软件包一起使用。除了创建一个公开可用的T1加权图谱（http://www.brainmap.wisc.edu/monkey.html）外，还创建了概率性组织分类图谱和T2加权图谱。这些图谱与Saleem, K.S.和Logothetis, N.K.（2006年）图谱中的MRI体积对齐，提供了与组织学切片的明确联系。此外，我们还创建了一种变换，以便将这些图谱与CARET中基于F99表面的图谱集成。预计这些工具将有助于促进非人类灵长类物种中基于体素的成像方法，这反过来可能会增进我们对脑功能、发育和进化的理解。
