Hutchings Matthew I, Palmer Tracy, Harrington Dean J, Sutcliffe Iain C
School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK.
Trends Microbiol. 2009 Jan;17(1):13-21. doi: 10.1016/j.tim.2008.10.001. Epub 2008 Dec 6.
Gram-positive bacterial lipoproteins are a functionally diverse and important class of peripheral membrane proteins. Recent advances in molecular biology and the availability of whole genome sequence data have overturned many long-held assumptions about the export and processing of these proteins, most notably the recent discovery that not all lipoproteins are exported as unfolded substrates through the general secretion pathway. Here, we review recent discoveries concerning the export and processing of these proteins, their role in virulence in Gram-positive bacteria and their potential as vaccine candidates or targets for new antimicrobials.
革兰氏阳性菌脂蛋白是一类功能多样且重要的外周膜蛋白。分子生物学的最新进展以及全基因组序列数据的可得性颠覆了许多长期以来关于这些蛋白输出和加工的假设，最显著的是最近发现并非所有脂蛋白都是通过一般分泌途径作为未折叠底物输出的。在此，我们综述了关于这些蛋白输出和加工、它们在革兰氏阳性菌毒力中的作用以及它们作为疫苗候选物或新型抗菌药物靶点的潜力的最新发现。
