Gladen B C, Rogan W J
Statistics and Biomathematics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.
J Pediatr. 1991 Jul;119(1 Pt 1):58-63. doi: 10.1016/s0022-3476(05)81039-x.
Determining whether early developmental effects of perinatal exposure to polychlorinated biphenyls (PCBs) or dichlorodiphenyl dichloroethene (DDE) persist.
Cohort followed from birth; ages now 5 1/2 to 10 1/2 years.
General community.
Volunteer sample of 859 children, of whom 712 had been examined with the McCarthy Scales of Children's Abilities at 3, 4, or 5 years; 506 sent report cards.
None.
Neither transplacental nor breast-feeding exposure to PCBs or DDE affected McCarthy scores at 3, 4, or 5 years. There was no statistically significant relationship between poorer grades and PCB or DDE exposure by either route.
The deficits seen in these children on the Bayley Scales of Infant Development through 2 years of age are no longer apparent.
确定围产期接触多氯联苯（PCBs）或二氯二苯二氯乙烯（DDE）的早期发育影响是否持续存在。
从出生开始追踪队列研究；目前年龄为5.5至10.5岁。
普通社区。
859名儿童的志愿者样本，其中712名儿童在3、4或5岁时接受了麦卡锡儿童能力量表测试；506名儿童提交了成绩单。
无。
经胎盘或母乳喂养接触PCBs或DDE均未影响3、4或5岁时的麦卡锡评分。两种途径的PCB或DDE暴露与较差成绩之间均无统计学上的显著关系。
这些儿童在2岁前贝利婴儿发育量表上出现的缺陷不再明显。
