大脑中谷胱甘肽的消耗会破坏大鼠和小鼠在Y迷宫中的短期空间记忆。
Glutathione depletion in the brain disrupts short-term spatial memory in the Y-maze in rats and mice.
作者信息
Dean Olivia, Bush Ashley I, Berk Michael, Copolov David L, van den Buuse Maarten
机构信息
Mental Health Research Institute, 155 Oak Street, Parkville, Victoria 3052, Australia.
出版信息
Behav Brain Res. 2009 Mar 2;198(1):258-62. doi: 10.1016/j.bbr.2008.11.017. Epub 2008 Nov 18.
Oxidative stress and reduced brain glutathione (GSH) levels have been reported in psychiatric illnesses including schizophrenia and bipolar disorder. However the role of GSH in cognitive impairment in the illness remains unclear. Treatment of Sprague-Dawley rats and C57Bl/6 mice with 2-cyclohexene-1-one (CHX) dose-dependently reduced striatal and frontal cortical GSH levels similar to those in schizophrenia. In both species, GSH depletion resulted in disruption of short-term spatial recognition memory in a Y-maze test. In conclusion, GSH depletion induces cognitive impairment, which may be relevant to the role of GSH in psychiatric illnesses.
据报道，在包括精神分裂症和双相情感障碍在内的精神疾病中存在氧化应激和脑内谷胱甘肽（GSH）水平降低的情况。然而，GSH在这些疾病的认知障碍中所起的作用仍不清楚。用2-环己烯-1-酮（CHX）对斯普拉格-道利大鼠和C57Bl/6小鼠进行处理，GSH水平呈剂量依赖性降低，类似于精神分裂症患者的情况。在这两个物种中，GSH耗竭均导致Y迷宫试验中的短期空间识别记忆受到破坏。总之，GSH耗竭会诱发认知障碍，这可能与GSH在精神疾病中的作用相关。
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