Department of Reproductive Biology and Cytogenetics, Centre Hospitalier Poissy, Saint Germain, France.
Fertil Steril. 2010 Mar 1;93(4):1347.e1-5. doi: 10.1016/j.fertnstert.2008.10.059. Epub 2008 Dec 4.
To study the chromosomal content of spermatozoa selected by intracytoplasmic morphologically selected sperm injection (IMSI) in cases of macrocephalic sperm head syndrome.
Case report.
Obstetrics, gynecology, urology, and reproductive biology departments.
PATIENT(S): Two infertile patients with large-headed spermatozoa.
INTERVENTION(S): Fluorescence in situ hybridization on selected spermatozoa with normal-sized heads after IMSI selection.
MAIN OUTCOME MEASURE(S): Percentages of polyploid, diploid, haploid aneuploid, and normal spermatozoa.
RESULT(S): Of the six spermatozoa that could be selected, all were haploid but aneuploid.
CONCLUSION(S): Absence of normal haploid spermatozoa among high magnification-selected spermatozoa contraindicated IMSI for these two patients.
研究在巨头精子综合征患者中，通过胞质内形态选择精子注射（IMSI）选择的精子的染色体含量。
病例报告。
妇产科、泌尿科和生殖生物学系。
两名患有大头精子的不育患者。
在 IMSI 选择后对具有正常头部的精选精子进行荧光原位杂交。
多倍体、二倍体、单倍体非整倍体和正常精子的百分比。
在可选择的 6 个精子中，均为单倍体但非整倍体。
高倍镜选择的精子中不存在正常的单倍体精子，这两个患者不适合 IMSI。
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