Compton Wilson M, Saha Tulshi D, Conway Kevin P, Grant Bridget F
Division of Epidemiology, Services and Prevention Research, National Institute on Drug Abuse, National Institutes of Health, 6001 Executive Boulevard, MSC 9589, Bethesda, MD 20892-9589, USA.
Drug Alcohol Depend. 2009 Mar 1;100(3):221-7. doi: 10.1016/j.drugalcdep.2008.10.009. Epub 2008 Dec 4.
Cannabis consumption is central to diagnosis of cannabis use disorders; yet, most research on cannabis disorders has focused just on diagnosis or criteria. The present study examines the ability of a frequency and quantity measure of cannabis use as well as cannabis abuse and dependence criteria to discriminate between individuals across the cannabis use disorder continuum.
A representative sample of USA adults in 2001-2002 (N=43,093) were queried about the past year frequency of cannabis use and each Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition (DSM-IV) cannabis abuse and dependence criterion. Factor analysis and item response theory (IRT) models were used to define the relationship between observed responses and the underlying unobserved latent trait (cannabis use disorder severity) among past year cannabis users (n=1603).
Factor analyses demonstrated a good fit for a one-factor model both with and without the cannabis use criterion and no differential criterion functioning was demonstrated across sex. The IRT model including the cannabis use criterion had discriminatory power comparable to the model without the cannabis use criterion and exceeded the informational value of the model without the cannabis use criterion in mild and moderate ranges of the severity continuum.
Factor and IRT analyses disprove the validity of the DSM-IV abuse and dependence distinction: A single dimension represented the criteria rather than the two implied by the separate abuse/dependence categories. IRT models identified some dependence criteria to be among the mildest and some abuse criteria to be among the most severe--results inconsistent with the interpretation of DSM-IV cannabis abuse as a milder disorder or prodrome of cannabis dependence. The consumption criterion defined the mild end of the cannabis use disorder continuum and its excellent psychometric properties supported its consideration for inclusion in the next edition of DSM as a criterion for cannabis use disorders. Additional work is needed to identify candidate consumption criteria across all drugs that apply to the milder end of the severity continuum while also improving overall model performance and clinical diagnostic utility.
大麻消费是大麻使用障碍诊断的核心;然而,大多数关于大麻障碍的研究仅关注诊断或标准。本研究考察了大麻使用频率和数量测量以及大麻滥用和依赖标准区分大麻使用障碍连续体上个体的能力。
对2001 - 2002年美国成年人的代表性样本(N = 43,093)询问过去一年大麻使用频率以及《精神障碍诊断与统计手册(第四版)》(DSM - IV)中每条大麻滥用和依赖标准。使用因子分析和项目反应理论(IRT)模型来确定过去一年大麻使用者(n = 1603)中观察到的反应与潜在未观察到的潜在特质(大麻使用障碍严重程度)之间的关系。
因子分析表明,无论有无大麻使用标准,单因素模型拟合良好,且未显示出性别间的标准功能差异。包含大麻使用标准的IRT模型具有与不包含该标准的模型相当的区分能力,并且在严重程度连续体的轻度和中度范围内超过了不包含大麻使用标准的模型的信息价值。
因子分析和IRT分析反驳了DSM - IV中滥用和依赖区分的有效性:单一维度代表了这些标准,而非单独的滥用/依赖类别所暗示的两个维度。IRT模型确定一些依赖标准是最轻微的,而一些滥用标准是最严重的——这些结果与将DSM - IV中的大麻滥用解释为较轻障碍或大麻依赖前驱症状的观点不一致。消费标准定义了大麻使用障碍连续体的轻度端点,其出色的心理测量特性支持将其纳入DSM的下一版作为大麻使用障碍的标准。需要开展更多工作来确定适用于严重程度连续体较轻端点的所有药物的候选消费标准,同时提高整体模型性能和临床诊断效用。