Harwood John L, Guschina Irina A
Cardiff University, UK.
Biochimie. 2009 Jun;91(6):679-84. doi: 10.1016/j.biochi.2008.11.004. Epub 2008 Nov 27.
Eukaryotic algae are a very diverse group of organisms that are key components of ecosystems ranging from deserts to the Antarctic. They account for over half of the primary production at the base of food chains. The lipids of different classes are varied and contain unusual compounds not found in other phyla. In this short review, we introduce the major cellular lipids and their fatty acids and then describe how the latter (particularly the polyunsaturated fatty acids, PUFAs) are synthesised. The discovery of different elongases and desaturases important for PUFA production is detailed and their application for biotechnology described. Finally, the potential for algae in commercial applications is discussed, particularly in relation to the production of very long chain PUFAs and biofuel.
真核藻类是一类非常多样的生物,是从沙漠到南极等各种生态系统的关键组成部分。它们在食物链基础的初级生产中占比超过一半。不同类别的脂质各不相同,含有其他门中未发现的特殊化合物。在这篇简短的综述中,我们介绍了主要的细胞脂质及其脂肪酸,然后描述了后者(特别是多不饱和脂肪酸,PUFAs)是如何合成的。详细介绍了对PUFA生产重要的不同延长酶和去饱和酶的发现,并描述了它们在生物技术中的应用。最后,讨论了藻类在商业应用中的潜力,特别是与极长链PUFAs的生产和生物燃料相关的潜力。