Agrawal Amit, Balpande D N, Khan A, Vagh S J, Shukla Samarth, Chopra Sumit
Division of Neurosurgery, Department of Surgery, Datta Meghe Institute of Medical Sciences, Sawangi (Meghe), Wardha, India.
Pediatr Neurosurg. 2008;44(6):471-3. doi: 10.1159/000180301. Epub 2008 Dec 10.
A 9-year-old female child presented with rapid neurological deterioration. Clinical features and imaging findings were suggestive of high-grade malignancy, and hematological investigations were suggestive of sickle cell trait. Histopathology showed features of low-grade malignancy and extensive intratumoral sickling. We hypothesize that the vicious cycle of hypoxia, sickling, thrombosis, ischemia and infarction resulted in the extensive tumor necrosis in the present case causing the initial symptoms and rapid deterioration in the condition of the patient.
一名9岁女童出现快速的神经功能恶化。临床特征和影像学检查结果提示为高级别恶性肿瘤，血液学检查提示为镰状细胞性状。组织病理学显示为低级别恶性肿瘤特征及广泛的肿瘤内镰状化。我们推测，在本病例中，缺氧、镰状化、血栓形成、缺血和梗死的恶性循环导致了广泛的肿瘤坏死，从而引发了患者的初始症状和病情快速恶化。
