Du Ming, Wang Cong, Zhang Lanwei
College of Food Science & Engineering, Harbin Institute of Technology, Harbin 150090, China.
Wei Sheng Yan Jiu. 2008 Sep;37(5):597-9.
To investigate the effect of bovine colostrum protein (BCP) on bone mineral density (BMD) in ovariectomized (ovx) rats.
48 female Sprague-Dawley rats of clean grade were ovariectomized and another 12 rats received a sham operation. The ovx rats were randomly separated into 4 groups: ovx control, ovx low-does, ovx media dose, and ovx high-dose. BCP at the doses of 0.20, 1.00 and 2.00 g/(kg bw x d) were applied in rat diet, and the rats were gavaged once per day for 12 weeks. BMD (at proximal, middle of diaphysis, and distal end) was measured by dual energy X-ray absorptiomery, and the body weight, length and weight of thighbone were measured also.
The bone density, bone weight, bone weight/length and bone weight/body weight in all dosages BCP groups were significantly higher than those in ovx groups.
BCP at the dose of 0.20 g/(kg bw x d) increase femur bone density at proximal and middle segment, and distal end in ovx rat.
研究牛初乳蛋白（BCP）对去卵巢（ovx）大鼠骨密度（BMD）的影响。
将48只清洁级雌性Sprague-Dawley大鼠去卵巢，另12只大鼠接受假手术。将去卵巢大鼠随机分为4组：去卵巢对照组、去卵巢低剂量组、去卵巢中剂量组和去卵巢高剂量组。在大鼠饮食中添加剂量为0.20、1.00和2.00 g/（kg体重×天）的BCP，大鼠每天灌胃1次，持续12周。通过双能X线吸收法测量骨密度（在骨干近端、中段和远端），并测量体重、体长和股骨重量。
所有剂量BCP组的骨密度、骨重量、骨重量/长度和骨重量/体重均显著高于去卵巢组。
剂量为0.20 g/（kg体重×天）的BCP可增加去卵巢大鼠股骨近端、中段和远端的骨密度。
