Shore Gordon C, Nguyen Mai
Department of Biochemistry and Goodman Cancer Center, McGill University, Montreal QCH3G1Y6, Canada.
Cell. 2008 Dec 12;135(6):1004-6. doi: 10.1016/j.cell.2008.11.029.
The Bcl-2 family protein Bax is a key effector of apoptosis. Lovell et al. (2008) now describe the reconstitution and regulation in liposomes of tBid-mediated membrane penetration and oligomerization of Bax. These and other recent studies shed new light on the control of permeabilization of the mitochondrial outer membrane during apoptosis.
Bcl-2家族蛋白Bax是细胞凋亡的关键效应因子。Lovell等人（2008年）现在描述了脂质体中tBid介导的Bax膜穿透和寡聚化的重组及调控。这些研究以及其他近期研究为细胞凋亡过程中线粒体外膜通透性的控制提供了新的线索。
