Department of Biochemistry, McMaster University, Hamilton, Ontario L8S 4L8, Canada.
Cell. 2012 Dec 7;151(6):1179-84. doi: 10.1016/j.cell.2012.11.013.
Regulation of apoptosis by Bcl-2 family proteins is a paradigm for complex protein-protein and protein-membrane systems. Elucidating the molecular mechanisms of these interactions in vitro in live cells and in animal studies has been significantly enhanced by using fluorescence techniques.
Bcl-2 家族蛋白对细胞凋亡的调控是复杂的蛋白质-蛋白质和蛋白质-膜系统的范例。荧光技术的应用显著促进了在活细胞和动物研究中对这些相互作用的分子机制的阐明。
