用于乳腺癌细胞体内分子靶向的异功能金纳米棒工程
Engineering of hetero-functional gold nanorods for the in vivo molecular targeting of breast cancer cells.
作者信息
Eghtedari Mohammad, Liopo Anton V, Copland John A, Oraevsky Alexander A, Motamedi Massoud
机构信息
Center for Biomedical Engineering, The University of Texas Medical Branch in Galveston, 301 University Boulevard, UTMB Route 0456, Galveston, Texas 77555, USA.
出版信息
Nano Lett. 2009 Jan;9(1):287-91. doi: 10.1021/nl802915q.
Abstract
A novel technique is described to functionalize gold nanorods (GNRs) allowing for in vivo targeting of breast cancer tumors grown in athymic nude mice. GNRs were functionalized by covalent attachment of Herceptin (HER), a monoclonal antibody that enables molecular recognition of breast cancer cells expressing highly specific tumor associated antigens, and poly(ethylene glycol) (PEG) which obscures particles against the reticuloendothelial system in the body. The stability and functionality of fabricated particles (Her-PEG GNRs) were demonstrated in vitro in the presence of blood and then in vivo in nude mice model for breast cancer. The results demonstrate successful tumor accumulation of functionalized gold nanorods within HER2/neu overexpressing breast tumors in tumor-bearing nude mice and support the notions that GNRs can be used for molecular imaging of tumor.
摘要
描述了一种使金纳米棒（GNRs）功能化的新技术，该技术可实现对无胸腺裸鼠体内生长的乳腺癌肿瘤进行体内靶向。通过共价连接赫赛汀（HER）对GNRs进行功能化，赫赛汀是一种单克隆抗体，能够分子识别表达高度特异性肿瘤相关抗原的乳腺癌细胞，以及聚乙二醇（PEG），后者可使颗粒在体内避开网状内皮系统。在有血液存在的体外环境以及乳腺癌裸鼠模型的体内环境中，均证明了制备的颗粒（Her-PEG GNRs）的稳定性和功能性。结果表明，功能化的金纳米棒在荷瘤裸鼠中HER2/neu过表达的乳腺肿瘤内成功实现肿瘤蓄积，支持了金纳米棒可用于肿瘤分子成像的观点。
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