有机合成中的苯并噻嗪类化合物。对映体纯的4-取代喹诺酮类化合物的制备。

Benzothiazines in organic synthesis. The preparation of enantiomerically pure 4-substituted quinolones.

作者信息

Harmata Michael, Hong Xuechuan

机构信息

Department of Chemistry, University of Missouri-Columbia, Columbia, MO 65203, USA.

出版信息

Org Lett. 2007 Jul 5;9(14):2701-4. doi: 10.1021/ol0710358. Epub 2007 Jun 8.

DOI:10.1021/ol0710358

PMID:17555325

Abstract

3,4-Dihydroquinolin-2(1H)-ones have potential biological and pharmacological significance. Enantiomerically pure benzothiazines, readily available via an intramolecular addition of a sulfoximine-stabilized carbanion to an alpha,beta-unsaturated ester, could be used as templates for making a series of enantiomerically pure 3,4-dihydroquinolin-2(1H)-ones under mild conditions.

摘要

3,4-二氢喹啉-2(1H)-酮具有潜在的生物学和药理学意义。通过亚磺酰亚胺稳定的碳负离子分子内加成到α,β-不饱和酯上可容易得到的对映体纯的苯并噻嗪，可在温和条件下用作制备一系列对映体纯的3,4-二氢喹啉-2(1H)-酮的模板。