Rittà Massimo, De Andrea Marco, Mondini Michele, Mazibrada Jasenka, Giordano Carlo, Pecorari Giancarlo, Garzaro Massimiliano, Landolfo Vincenzo, Schena Marina, Chiusa Luigi, Landolfo Santo
Department of Public Health and Microbiology, Medical School of Turin, Turin, Italy.
Head Neck. 2009 Mar;31(3):318-27. doi: 10.1002/hed.20977.
The aim of this study was to determine whether the aberrant expression of cell-cycle or immune-response markers together with human papillomavirus (HPV) positivity impacts patient survival in different head and neck squamous cell carcinoma (HNSCC) subsets.
A total of 59 HNSCC specimens were analyzed for expression of cell cycle and proliferation markers, and macrophage infiltration. HPV was evaluated by polymerase chain reaction and DNA sequencing.
The HPV presence in oropharynx carcinoma was associated with survival advantage. Low Ki67 expression was associated with favorable outcome in oropharynx and oral cavity carcinoma. A more favorable outcome was associated with low cyclin E expression in larynx carcinoma and with low p53 expression in squamous cell carcinoma (SCC) of the oral cavity. A direct correlation between macrophage infiltration and tumor proliferation index was observed irrespective of the tumor subset.
The assessment of proliferation, viral, and immunologic profiles may be crucial to finding beneficial treatments for the different HNSCC subsets.
本研究旨在确定细胞周期或免疫反应标志物的异常表达以及人乳头瘤病毒（HPV）阳性是否会影响不同头颈部鳞状细胞癌（HNSCC）亚组患者的生存率。
共分析了59例HNSCC标本的细胞周期和增殖标志物表达以及巨噬细胞浸润情况。通过聚合酶链反应和DNA测序评估HPV。
口咽癌中HPV的存在与生存优势相关。低Ki67表达与口咽癌和口腔癌的良好预后相关。更有利的预后与喉癌中低细胞周期蛋白E表达以及口腔鳞状细胞癌（SCC）中低p53表达相关。无论肿瘤亚组如何，均观察到巨噬细胞浸润与肿瘤增殖指数之间存在直接相关性。
评估增殖、病毒和免疫特征对于为不同的HNSCC亚组找到有益的治疗方法可能至关重要。
