Nisbet D R, Forsythe J S, Shen W, Finkelstein D I, Horne M K
Department of Materials Engineering, Division of Biological Engineering, Monash University, Victoria 3800, Australia.
J Biomater Appl. 2009 Jul;24(1):7-29. doi: 10.1177/0885328208099086. Epub 2008 Dec 12.
Electrospinning has been employed extensively in tissue engineering to generate nanofibrous scaffolds from either natural or synthetic biodegradable polymers to simulate the cellular microenvironment. Electrospinning rapidly produces fibers of the nanolength scale and the process offers many opportunities to tailor the physical, chemical, and biological properties of a material for specific applications and cellular environments. There is growing evidence that nanofibers amplify certain biological responses such as contact guidance and differentiation, however this has not been fully exploited in tissue engineering. This review addresses the cellular interactions with electrospun scaffolds, with particular focus on neural, bone, cartilage, and vascular tissue regeneration. Some aspects of scaffold design, including architectural properties, surface functionalization and materials selection are also addressed.
静电纺丝技术已在组织工程中得到广泛应用，它能利用天然或合成的可生物降解聚合物制备纳米纤维支架，以模拟细胞微环境。静电纺丝可快速生产纳米级长度的纤维，该过程为根据特定应用和细胞环境来调整材料的物理、化学和生物学特性提供了诸多机会。越来越多的证据表明，纳米纤维能增强某些生物反应，如接触导向和分化，但这一点在组织工程中尚未得到充分利用。本文综述了细胞与静电纺丝支架的相互作用，特别关注神经、骨、软骨和血管组织的再生。同时还讨论了支架设计的一些方面，包括结构特性、表面功能化和材料选择。
