Marrakchi Slaheddine, Turki Hamida
Department of Dermatology, Hédi Chaker Hospital, 3029 Sfax, Tunisia.
Recent Pat Inflamm Allergy Drug Discov. 2008 Nov;2(3):226-31. doi: 10.2174/187221308786241901.
Allergic contact dermatitis (ACD) is a common skin disorder that has a high socio-economic impact with regard to the increasing number of industrial allergens that has potential harmful effect on the skin of manual workers. Its management relies on the use of topical anti-inflammatory drugs as well as the avoidance of the allergens inducing the disease. However, with regard to the ubiquitous character of many chemicals in the environment, treatment of the disease remains unsatisfactory. Understanding the molecular basis of the disease is of major importance in prospect of designing new therapeutic modalities. In this article, the various stages of the disease are reviewed as well as the recent advances in the understanding of the molecular basis of the mechanisms of the disease that would help to conceive new concepts for drug intervention. The article also reviews some of the recent patent relevant to the field.
过敏性接触性皮炎（ACD）是一种常见的皮肤疾病，随着工业过敏原数量的增加，其对社会经济产生了重大影响，这些过敏原可能会对手工劳动者的皮肤造成潜在危害。其治疗依赖于使用局部抗炎药物以及避免诱发该疾病的过敏原。然而，鉴于环境中许多化学物质无处不在的特性，该疾病的治疗仍然不尽人意。了解该疾病的分子基础对于设计新的治疗方法至关重要。在本文中，我们回顾了该疾病的各个阶段，以及在理解该疾病机制的分子基础方面的最新进展，这些进展将有助于构思药物干预的新概念。本文还回顾了该领域的一些最新专利。
