Cavalcanti Adriano, Shirinzadeh Bijan, Freitas Robert A, Kretly Luiz C
CAN Center for Automation in Nanobiotech, Herminio Lemos 449, Sao Paulo, SP 01540 Brazil.
Recent Pat Nanotechnol. 2007;1(1):1-10. doi: 10.2174/187221007779814745.
This work describes an innovative medical nanorobot architecture based on important discoveries in nanotechnology, integrated circuit patents, and some publications, directly or indirectly related to one of the most challenging new fields of science: molecular machines. Thus, the architecture described in this paper reflects, and is supported by, some remarkable recent achievements and patents in nanoelectronics, wireless communication and power transmission techniques, nanotubes, lithography, biomedical instrumentation, genetics, and photonics. We also describe how medicine can benefit from the joint development of nanodevices which are derived, and which integrate techniques, from artificial intelligence, nanotechnology, and embedded smart sensors. Teleoperated surgical procedures, early disease diagnosis, and pervasive patient monitoring are some possible applications of nanorobots, reflecting progress along a roadmap for the gradual and practical development of nanorobots. To illustrate the described nanorobot architecture, a computational 3D approach with the application of nanorobots for diabetes is simulated using clinical data. Theoretical and practical analysis of system integration modeling is one important aspect for supporting the rapid development in the emerging field of nanotechnology. This provides useful directions for further research and development of medical nanorobotics and suggests a time frame in which nanorobots may be expected to be available for common utilization in therapeutic and medical procedures.
这项工作描述了一种创新的医学纳米机器人架构，该架构基于纳米技术的重要发现、集成电路专利以及一些与最具挑战性的新科学领域之一：分子机器直接或间接相关的出版物。因此，本文所描述的架构反映了并得到了纳米电子学、无线通信和电力传输技术、纳米管、光刻技术、生物医学仪器、遗传学和光子学等领域近期一些卓越成就和专利的支持。我们还描述了医学如何从纳米设备的联合开发中受益，这些纳米设备源自人工智能、纳米技术和嵌入式智能传感器，并整合了相关技术。远程操作手术程序、早期疾病诊断和全面的患者监测是纳米机器人的一些可能应用，反映了纳米机器人逐步实际发展路线图上的进展。为了说明所描述的纳米机器人架构，使用临床数据对应用纳米机器人治疗糖尿病的计算三维方法进行了模拟。系统集成建模的理论和实践分析是支持纳米技术新兴领域快速发展的一个重要方面。这为医学纳米机器人技术的进一步研发提供了有用的方向，并提出了一个时间框架，预计在这个时间框架内纳米机器人可用于治疗和医疗程序的普遍应用。
