van Kaam A H, Koopman-Esseboom C, Sulkers E J, Sauer P J, van der Paauw C G, Tuinstra L G
Academisch Ziekenhuis Rotterdam-Sophia Kinderziekenhuis, afd. Kindergeneeskunde, subafd. Pasgeborenen.
Ned Tijdschr Geneeskd. 1991 Aug 3;135(31):1399-403.
In a longitudinal study involving 17 women, PCB concentrations (PCBs 138, 153 and 180) were determined in cord blood (17 newborns), breast milk (10 women), maternal adipose tissue (8 women), maternal plasma collected during the last trimester of pregnancy (17 women) and maternal plasma collected 10 days post partum (7 women). Significant correlations were found (p less than 0.05) between PCB levels in cord blood, breast milk and adipose tissue and maternal plasma collected before birth, and between breast milk and maternal plasma collected post partum. In 2 vegetarian women the PCB levels in maternal plasma and cord blood were significantly lower than in the other women (p less than 0.05). If in future studies the PCB levels observed prove to be detrimental to child development, these correlations may offer the possibility of identifying a group of newborns at risk for occurrence of developmental defects due to PCB exposure before birth.
在一项涉及17名女性的纵向研究中，测定了脐带血（17名新生儿）、母乳（10名女性）、母体脂肪组织（8名女性）、妊娠晚期采集的母体血浆（17名女性）以及产后10天采集的母体血浆（7名女性）中的多氯联苯浓度（多氯联苯138、153和180）。在脐带血、母乳和脂肪组织中的多氯联苯水平与出生前采集的母体血浆之间，以及母乳与产后采集的母体血浆之间发现了显著相关性（p小于0.05）。在2名素食女性中，母体血浆和脐带血中的多氯联苯水平显著低于其他女性（p小于0.05）。如果在未来的研究中观察到的多氯联苯水平被证明对儿童发育有害，这些相关性可能提供一种可能性，即识别出一组因出生前接触多氯联苯而有发生发育缺陷风险的新生儿。
