Koopman-Esseboom C, Morse D C, Weisglas-Kuperus N, Lutkeschipholt I J, Van der Paauw C G, Tuinstra L G, Brouwer A, Sauer P J
Department of Pediatrics, Erasmus University, Rotterdam, The Netherlands.
Pediatr Res. 1994 Oct;36(4):468-73. doi: 10.1203/00006450-199410000-00009.
Dioxins [polychlorinated dibenzo-p-dioxins (PCDD), dibenzofurans (PCDF)] and polychlorinated biphenyls (PCB) are potentially hazardous compounds. Animal studies have demonstrated that PCDD, PCDF, and PCB can alter thyroid hormone homeostasis. We investigated thyroid hormone levels in 105 mother-infant pairs. To estimate maternal and infant exposure, four nonplanar PCB congeners were measured in maternal plasma during the last month of pregnancy and in umbilical cord plasma. Seventeen PCDD and PCDF congeners, three planar PCB congeners, and 23 nonplanar PCB congeners were measured in human milk. Higher PCDD, PCDF, and PCB levels in human milk, expressed as toxic equivalents, correlated significantly with lower plasma levels of maternal total triiodothyronine and total thyroxine, and with higher plasma-levels of TSH in the infants in the 2nd wk and 3rd mo after birth. Infants exposed to higher toxic equivalents levels had also lower plasma free thyroxine and total thyroxine levels in the 2nd wk after birth. We conclude that elevated levels of dioxins and PCB can alter the human thyroid hormone status.
二噁英[多氯代二苯并 - 对 - 二噁英（PCDD）、二苯并呋喃（PCDF）]和多氯联苯（PCB）是具有潜在危害的化合物。动物研究表明，PCDD、PCDF和PCB可改变甲状腺激素稳态。我们调查了105对母婴的甲状腺激素水平。为了评估母婴接触情况，在妊娠最后一个月的母体血浆和脐带血血浆中检测了四种非平面PCB同系物。在母乳中检测了17种PCDD和PCDF同系物、3种平面PCB同系物以及23种非平面PCB同系物。以毒性当量表示的母乳中较高的PCDD、PCDF和PCB水平，与母体总三碘甲状腺原氨酸和总甲状腺素的较低血浆水平显著相关，并且与出生后第2周和第3个月婴儿血浆中促甲状腺激素（TSH）的较高水平显著相关。暴露于较高毒性当量水平的婴儿在出生后第2周时血浆游离甲状腺素和总甲状腺素水平也较低。我们得出结论，二噁英和PCB水平升高会改变人体甲状腺激素状态。
