Ming Hsieh Department of Electrical Engineering, University of Southern California, Los Angeles, California, USA.
Magn Reson Med. 2010 Apr;63(4):858-64. doi: 10.1002/mrm.22315.
Three-dimensional (3D) first-pass myocardial perfusion imaging (MPI) is a promising alternative to conventional two-dimensional multislice MPI due to its contiguous spatial coverage that is beneficial for estimating the size of perfusion defects. Data acquisition at mid-diastole is a typical choice for 3D MPI yet is sensitive to arrhythmia and variations in R-R interval that are common in cardiac patients. End systole is the second longest quiescent cardiac phase and is known to be less sensitive to the R-R variability. Therefore, 3D MPI with systolic acquisition may be advantageous in patients with severe arrhythmia once it is proven to be comparable to diastolic MPI in subjects with negligible R-R variation. In this work, we demonstrate the feasibility of 3D MPI with systolic data acquisition in five healthy subjects. We performed 3D MPI experiments in which 3D perfusion data were acquired at both end-systole and mid-diastole of every R-R interval and analyzed the similarity between resulting time intensity curves (TIC) from the two data sets. The correlation between systolic and diastolic TICs was extremely high (mean = 0.9841; standard deviation = 0.0166), and there was a significant linear correlation between the two time intensity curve upslopes and peak enhancements (P < 0.001).
三维（3D）首过心肌灌注成像（MPI）是一种有前途的替代传统二维多层 MPI 的方法，因为它具有连续的空间覆盖范围，有利于估计灌注缺陷的大小。在舒张中期进行数据采集是 3D MPI 的典型选择，但对心律失常和心脏患者中常见的 R-R 间隔变化很敏感。收缩期是心脏的第二个最长静止期，已知对 R-R 变异性的敏感性较低。因此，一旦证明在 R-R 变化可忽略不计的受试者中，收缩期采集的 3D MPI 与舒张期 MPI 相当，那么在严重心律失常患者中，它可能具有优势。在这项工作中，我们在五名健康受试者中展示了使用收缩期数据采集进行 3D MPI 的可行性。我们进行了 3D MPI 实验，在每个 R-R 间隔的收缩末期和舒张中期采集 3D 灌注数据，并分析了两个数据集产生的时间强度曲线（TIC）之间的相似性。收缩期和舒张期 TIC 之间的相关性极高（平均值=0.9841；标准差=0.0166），并且两条时间强度曲线上升斜率和峰值增强之间存在显著的线性相关性（P<0.001）。
