Buck Christopher B, Lowy Douglas R
Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland 20892-4263, USA.
J Invest Dermatol. 2009 Jan;129(1):9-11. doi: 10.1038/jid.2008.302.
Merkel cell carcinoma (MCC) is an aggressive skin cancer that develops in individuals who are over the age of 50 or immunosuppressed. DNA from a new polyomavirus, MCPyV, was recently shown to be clonally integrated in several MCC cases. In this issue, Becker et al. demonstrate that MCPyV DNA can be isolated from 85% of primary European MCC specimens and their metastases, and Garneski et al. present data indicating that the percentage of Australian MCC cases containing MCPyV may be lower than that of North American cases. These reports support the possibility that MCPyV is etiologically involved in at least some cases of MCC.
默克尔细胞癌（MCC）是一种侵袭性皮肤癌，发生于50岁以上或免疫功能低下的个体。最近发现，一种新型多瘤病毒MCPyV的DNA在几例MCC病例中呈克隆性整合。在本期杂志中，贝克尔等人证明，85%的原发性欧洲MCC标本及其转移灶中可分离出MCPyV DNA，而加内斯基等人提供的数据表明，澳大利亚含有MCPyV的MCC病例百分比可能低于北美病例。这些报告支持了MCPyV在至少某些MCC病例中具有病因学作用的可能性。
