Hafner L, Beagley K, Timms P
Department of Life Sciences, Queensland University of Technology, Brisbane, Queensland, Australia.
Mucosal Immunol. 2008 Mar;1(2):116-30. doi: 10.1038/mi.2007.19. Epub 2008 Jan 9.
Chlamydia trachomatis causes genital tract infections that affect men, women, and children on a global scale. This review focuses on innate and adaptive immune responses in the female reproductive tract (FRT) to genital tract infections with C. trachomatis. It covers C. trachomatis infections and highlights our current knowledge of genital tract infections, serovar distribution, infectious load, and clinical manifestations of these infections in women. The unique features of the immune system of the FRT will be discussed and will include a review of our current knowledge of innate and adaptive immunity to chlamydial infections at this mucosal site. The use of animal models to study the pathogenesis of, and immunity to, Chlamydia infection of the female genital tract will also be discussed and a review of recent immunization and challenge experiments in the murine model of chlamydial FRT infection will be presented.
沙眼衣原体可引起生殖道感染，在全球范围内影响男性、女性和儿童。本综述聚焦于女性生殖道（FRT）对沙眼衣原体生殖道感染的固有免疫和适应性免疫反应。它涵盖了沙眼衣原体感染，并突出了我们目前对生殖道感染、血清型分布、感染负荷以及这些感染在女性中的临床表现的认识。将讨论FRT免疫系统的独特特征，包括对该黏膜部位沙眼衣原体感染的固有免疫和适应性免疫的现有认识综述。还将讨论使用动物模型研究女性生殖道衣原体感染的发病机制和免疫情况，并介绍沙眼衣原体FRT感染小鼠模型中近期免疫和攻毒实验的综述。
