TIPE2的晶体结构为免疫稳态提供了见解。
Crystal structure of TIPE2 provides insights into immune homeostasis.
作者信息
Zhang Xu, Wang Jiawei, Fan Chao, Li Hubo, Sun Honghong, Gong Shunyou, Chen Youhai H, Shi Yigong
机构信息
Center for Structural Biology and Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China.
出版信息
Nat Struct Mol Biol. 2009 Jan;16(1):89-90. doi: 10.1038/nsmb.1522. Epub 2008 Dec 14.
TNFAIP8-like 2 (TIPE2) has an essential role in immune homeostasis, yet the underlying mechanism remains enigmatic. The high-resolution crystal structure of TIPE2 reveals a previously uncharacterized fold that is different from the predicted fold of a death effector domain (DED). Strikingly, TIPE2 contains a large, hydrophobic central cavity that is poised for cofactor binding. These structural features will be important for understanding the functions of TIPE2 and other TNFAIP8 family proteins.
肿瘤坏死因子α诱导蛋白8样蛋白2（TIPE2）在免疫稳态中发挥着重要作用，但其潜在机制仍不清楚。TIPE2的高分辨率晶体结构揭示了一种以前未被描述的折叠方式，它不同于死亡效应结构域（DED）的预测折叠方式。引人注目的是，TIPE2含有一个大的疏水中心腔，可用于辅因子结合。这些结构特征对于理解TIPE2和其他TNFAIP8家族蛋白的功能将具有重要意义。
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