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[2,2,2-三氟-1-苯基磺酰氨基-1-(三氟甲基)乙基]膦酸二乙酯

Diethyl [2,2,2-trifluoro-1-phenyl-sulfonyl-amino-1-(trifluoro-meth-yl)eth-yl]phospho-nate.

作者信息

Wijeyesakere Sanjeeva J, Nasser Faik A, Kampf Jeff W, Aksinenko Alexey Y, Sokolov Vladimir B, Malygin Vladimir V, Makhaeva Galina F, Richardson Rudy J

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2008 Aug 1;64(Pt 8):o1425. doi: 10.1107/S1600536808020175. Epub 2008 Jul 5.

DOI:10.1107/S1600536808020175
PMID:19079747
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2600860/
Abstract

The title compound, C(13)H(16)F(6)NO(5)PS, is of inter-est with respect to inhibition of serine hydro-lases. Its structure contains a 1.8797 (13) Å P-C bond and two inter-molecular N-H⋯O=P hydrogen bonds, resulting in centrosymmetric dimers. An intra-molecular N-H⋯O=P hydrogen bond is also present.

摘要

标题化合物C(13)H(16)F(6)NO(5)PS在抑制丝氨酸水解酶方面具有重要意义。其结构包含一个1.8797 (13) Å的P-C键和两个分子间N-H⋯O=P氢键，形成中心对称二聚体。还存在一个分子内N-H⋯O=P氢键。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bad/2962058/9fbaf97105cf/e-64-o1425-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bad/2962058/0ca1f99a1c42/e-64-o1425-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bad/2962058/9fbaf97105cf/e-64-o1425-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bad/2962058/0ca1f99a1c42/e-64-o1425-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bad/2962058/9fbaf97105cf/e-64-o1425-fig2.jpg

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