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Kinetics and mechanism of inhibition of serine esterases by fluorinated carbethoxy 1-aminophosphonates.

作者信息

Makhaeva G F, Lushchekina S V, Serebryakova O G, Aksinenko A Yu, Goreva T V, Richardson R J, Martynov I V

机构信息

Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, Moscow Region, 142432, Russia.

出版信息

Dokl Biochem Biophys. 2013 Jul-Aug;451:203-6. doi: 10.1134/S1607672913040091. Epub 2013 Aug 23.

DOI:10.1134/S1607672913040091
PMID:23975401
Abstract
摘要

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Combined QSAR studies of inhibitor properties of O-phosphorylated oximes toward serine esterases involved in neurotoxicity, drug metabolism and Alzheimer's disease.O-磷酸肟类化合物对涉及神经毒性、药物代谢和阿尔茨海默病的丝氨酸酯酶抑制特性的定量构效关系研究
SAR QSAR Environ Res. 2012 Oct;23(7-8):627-47. doi: 10.1080/1062936X.2012.679690. Epub 2012 May 15.
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Diethyl [2,2,2-trifluoro-1-phenyl-sulfonyl-amino-1-(trifluoro-meth-yl)eth-yl]phospho-nate.[2,2,2-三氟-1-苯基磺酰氨基-1-(三氟甲基)乙基]膦酸二乙酯
Acta Crystallogr Sect E Struct Rep Online. 2008 Aug 1;64(Pt 8):o1425. doi: 10.1107/S1600536808020175. Epub 2008 Jul 5.
5
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J Comput Aided Mol Des. 2004 Mar;18(3):167-73. doi: 10.1023/b:jcam.0000035186.90683.f2.
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A stable preparation of hen brain neuropathy target esterase for rapid biochemical assessment of neurotoxic potential of organophosphates.
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Bioorg Khim. 1990 Nov;16(11):1500-8.
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[Inhibition of enzymatic activity of alpha-thrombin by low molecular weight synthetic inhibitor].[低分子量合成抑制剂对α-凝血酶酶活性的抑制作用]
Biokhimiia. 1992 Jan;57(1):21-6.