Kemp Stephen W P, Walsh Sarah K, Midha Rajiv
Department of Clinical Neuroscience, Faculty of Medicine, Hotchkiss Brain Institute, University of Calgary, Calgary, Alta, Canada.
Neurol Res. 2008 Dec;30(10):1030-8. doi: 10.1179/174313208X362505.
Despite the capacity for spontaneous axonal regeneration, recovery after severe peripheral nerve injury remains variable and often very poor. In addition, autologous nerve grafts, considered to be the 'gold standard' in nerve repair technique, are plagued by restricted donor tissue availability and donor site morbidity. Our primary objective is to highlight new and emerging methods of nerve repair, which have the potential to significantly improve both the functional and behavioral outcome after clinical nerve injury.
A critical analysis of nerve injury and regeneration literature concentrating on outcome measures from both immediate and chronically denervated experimental works was conducted.
Results of numerous works employing both growth factor and stem cell enhanced nerve guidance conduits have shown encouraging results. However, further research is needed to optimize guidance conduit dynamics, bioavailability and delivery of both growth factors and stem cells to enhance peripheral nerve regeneration and functional recovery.
This review discusses current animal and clinical growth factor and stem cell studies, specifically focusing on future bio-engineering approaches in developing a nerve guidance conduit in the future.
尽管存在轴突自发再生的能力，但严重周围神经损伤后的恢复情况仍存在差异，且往往非常不理想。此外，被视为神经修复技术“金标准”的自体神经移植，受到供体组织可用性受限和供体部位并发症的困扰。我们的主要目标是突出新出现的神经修复方法，这些方法有可能显著改善临床神经损伤后的功能和行为结果。
对神经损伤和再生文献进行了批判性分析，重点关注即时和长期去神经支配实验研究的结果指标。
众多使用生长因子和干细胞增强神经引导导管的研究结果令人鼓舞。然而，需要进一步研究以优化引导导管的动力学、生物利用度以及生长因子和干细胞的递送，以促进周围神经再生和功能恢复。
本综述讨论了当前的动物和临床生长因子及干细胞研究，特别关注未来开发神经引导导管的生物工程方法。
