Kucukosmanoglu E, Yazi D, Yesil O, Akkoc T, Gezer M, Ozdemir C, Bakirci N, Bahceciler N N, Barlan I B
Gaziantep University Medical Faculty. Department of Pediatrics. Gaziantep. Turkey.
Allergol Immunopathol (Madr). 2008 Sep-Oct;36(5):254-8. doi: 10.1016/s0301-0546(08)75219-4.
Cow's milk (CM) hypersensitivity is one of the most frequent hypersensitivities in infants. The objective of our study was to investigate the prevalence of immediate hypersensitivity to CM based on skin prick test results and to evaluate associated allergic conditions ascertained by questionnaire in infants living in Istanbul.
All infants born between June 2001 and May 2002 were recalled to the hospital according to their dates of birth, and 1015 infants aged between 8-18 months were included in the study. An interview was conducted with each mother and a questionnaire requesting data on cow's milk hypersensitivity and other allergic diseases was completed during this interview. A cow's milk skin prick test (SPT) was applied to all infants. An open CM challenge test was then carried out on infants with a positive SPT to CM.
Among the 1015 infants who underwent SPT, six (0.59 %) demonstrated immediate hyper-sensitivity to the CM allergen and three (0.29 %) developed a positive response to the CM challenge test. The results of the questionnaire revealed that 112 (11.0 %) of the infants had family history of allergic diseases, 96 infants (9.5 %) had a positive history of recurrent wheezing, and 166 (16.4 %) had a history of skin rash resembling atopic dermatitis.
Our results suggest that CM hyper-sensitivity, with its low prevalence, might not be a serious health concern in Turkish infants.
牛奶（CM）过敏是婴儿中最常见的过敏之一。我们研究的目的是根据皮肤点刺试验结果调查对CM速发型过敏的患病率，并通过问卷调查评估伊斯坦布尔婴儿中确定的相关过敏情况。
根据出生日期召回2001年6月至2002年5月期间出生的所有婴儿，1015名8至18个月大的婴儿纳入研究。对每位母亲进行访谈，并在访谈期间完成一份关于牛奶过敏和其他过敏性疾病数据的问卷。对所有婴儿进行牛奶皮肤点刺试验（SPT）。然后对CM-SPT呈阳性的婴儿进行开放性CM激发试验。
在接受SPT的1015名婴儿中，6名（0.59%）对CM过敏原表现出速发型过敏，3名（0.29%）对CM激发试验呈阳性反应。问卷结果显示，112名（11.0%）婴儿有过敏性疾病家族史，96名婴儿（9.5%）有复发性喘息阳性史，166名（16.4%）有类似特应性皮炎的皮疹史。
我们的结果表明，CM过敏患病率较低，可能不是土耳其婴儿严重的健康问题。
