Ristic J M, Marin C J, Baines E A, Herrtage M E
Queen's Veterinary School Hospital, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK.
J Vet Cardiol. 2001 Nov;3(2):13-9. doi: 10.1016/S1760-2734(06)70015-7.
PBV is the treatment of choice for humans with pulmonic stenosis and whilst this procedure has been used in dogs the longer term benefits remain to be evaluated.
The purpose of this study was to evaluate the long term effects of pulmonary balloon valvuloplasty (PBV) in dogs with congenital pulmonic stenosis, with respect to clinical signs, echocardiographic parameters and survival time. Methods - Pulmonic stenosis was diagnosed in 24 dogs between 1990-1999. Eighteen cases were treated with PBV, six were not treated.
Twelve of the treated cases were alive and asymptomatic at the time of writing. Follow up periods ranged from six months to nine years post PBV. Prior to treatment the mean Doppler pressure gradient across the pulmonic valve was 98mmHg, 24 hours post treatment the mean was 65mmHg and in the long term this was maintained at 64mmHg. Three of the dogs (17 per cent) treated with PBV restenosed during the follow up period. Four of the six untreated dogs were alive at the time of writing, two to four and a half years after presentation. The mean Doppler gradient for this group was 89 mm Hg on presentation.
At this stage in the follow up period there is no significant difference in survival times between the treated and untreated groups. However, symptomatic dogs with pulmonic stenosis treated with PBV have experienced a reduction in clinical signs and therefore an improved quality of life.
经皮球囊肺动脉瓣成形术（PBV）是人类肺动脉狭窄的首选治疗方法，虽然该手术已应用于犬类，但长期益处仍有待评估。
本研究的目的是评估先天性肺动脉狭窄犬经皮球囊肺动脉瓣成形术（PBV）的长期效果，包括临床症状、超声心动图参数和生存时间。方法——1990年至1999年间，24只犬被诊断为肺动脉狭窄。18例接受了PBV治疗，6例未接受治疗。
在撰写本文时，12例接受治疗的病例存活且无症状。PBV术后随访时间为6个月至9年。治疗前，肺动脉瓣平均多普勒压力阶差为98mmHg，治疗后24小时平均为65mmHg，长期维持在64mmHg。17%（3只）接受PBV治疗的犬在随访期间发生再狭窄。6只未治疗的犬中，4只在撰写本文时存活，就诊后2至4年半。该组就诊时平均多普勒压力阶差为89mmHg。
在随访的这个阶段，治疗组和未治疗组的生存时间没有显著差异。然而，接受PBV治疗的有症状肺动脉狭窄犬的临床症状有所减轻，因此生活质量得到改善。
