Gisladottir Berglind, Gudmundsdottir Sigridur, Brown Linton, Jonsson Zophonias O, Magnadottir Bergljot
Institute for Experimental Pathology, University of Iceland, Keldur v. Vesturlandsveg, 112 Reykjavik, Iceland.
Fish Shellfish Immunol. 2009 Feb;26(2):210-9. doi: 10.1016/j.fsi.2008.03.015. Epub 2008 Apr 1.
Pentraxins are important molecules in innate defence and play a role in the acute phase response of both mammals and fish. Isolation of cod pentraxins by affinity chromatography using phosphorylcholine agarose revealed two pentraxin-like proteins, referred to as PI and PII proteins. These varied in their overall charge, pentameric and subunit molecular size, glycosylation and N-terminal amino acid sequences. The PI protein was homologous with the CRP-like pentraxin previously described in cod whereas the PII protein was a new CRP homologue, which was characterized by substantial individual heterogeneity with regard to subunit size and relative density. The results indicate considerable genetic variations in the cod pentraxins.
