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C反应蛋白（CRP）和血清淀粉样蛋白P（SAP）样基因的系统发育和表达分析揭示了鱼类中的两个不同群体。

Phylogeny and expression analysis of C-reactive protein (CRP) and serum amyloid-P (SAP) like genes reveal two distinct groups in fish.

作者信息

Lee P T, Bird S, Zou J, Martin S A M

机构信息

Scottish Fish Immunology Research Centre, Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK.

Science & Engineering, University of Waikato, Private Bag 3105, Hamilton 3240, New Zealand.

出版信息

Fish Shellfish Immunol. 2017 Jun;65:42-51. doi: 10.1016/j.fsi.2017.03.037. Epub 2017 Mar 20.

DOI:10.1016/j.fsi.2017.03.037
PMID:28336487
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5446266/
Abstract

The acute phase response (APR) is an early innate immune function that is initiated by inflammatory signals, leading to the release of acute phase proteins to the bloodstream to re-establish homeostasis following microbial infection. In this study we analysed the Atlantic salmon (Salmo salar) whole-genome database and identified five C-reactive protein (CRP)/serum amyloid P component (SAP) like molecules namely CRP/SAP-1a, CRP/SAP-1b, CRP/SAP-1c, CRP/SAP-2 and CRP/SAP-3. These CRP/SAP genes formed two distinct sub-families, a universal group (group I) present in all vertebrates and a fish/amphibian specific group (group II). Salmon CRP/SAP-1a, CRP/SAP-1b and CRP/SAP-1c and CRP/SAP-2 belong to the group I family whilst salmon CRP/SAP-3 is a member of group II. Gene expression analysis showed that the salmon CRP/SAP-1a as well as serum amyloid A-5 (SAA-5), one of the major acute phase proteins, were significantly up-regulated by recombinant cytokines (rIL-1β and rIFNγ) in primary head kidney cells whilst the other four CRP/SAPs remained refractory. Furthermore, SAA-5 was produced as the main acute phase protein (APP) in Atlantic salmon challenged with Aeromonas salmonicida (aroA(-) strain) whilst salmon CRP/SAPs remained unaltered. Overall, these data illustrate the potential different functions of expanded salmon CRP/SAPs to their mammalian homologues.

摘要

急性期反应（APR）是一种早期固有免疫功能，由炎症信号引发，导致急性期蛋白释放到血液中，以便在微生物感染后重新建立体内平衡。在本研究中，我们分析了大西洋鲑（Salmo salar）全基因组数据库，并鉴定出5种C反应蛋白（CRP）/血清淀粉样蛋白P成分（SAP）类似分子，即CRP/SAP-1a、CRP/SAP-1b、CRP/SAP-1c、CRP/SAP-2和CRP/SAP-3。这些CRP/SAP基因形成了两个不同的亚家族，一个是所有脊椎动物中都存在的通用组（I组），另一个是鱼类/两栖动物特有的组（II组）。鲑鱼CRP/SAP-1a、CRP/SAP-1b、CRP/SAP-1c和CRP/SAP-2属于I组家族，而鲑鱼CRP/SAP-3是II组的成员。基因表达分析表明，在原代头肾细胞中，鲑鱼CRP/SAP-1a以及主要急性期蛋白之一的血清淀粉样蛋白A-5（SAA-5），被重组细胞因子（rIL-1β和rIFNγ）显著上调，而其他四种CRP/SAPs则无反应。此外，在用杀鲑气单胞菌（aroA(-)菌株）攻击的大西洋鲑中，SAA-5作为主要急性期蛋白（APP）产生，而鲑鱼CRP/SAPs则保持不变。总体而言，这些数据说明了扩展的鲑鱼CRP/SAPs与其哺乳动物同源物可能具有不同的功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6bd/5446266/4c88a557b3c4/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6bd/5446266/6b50ea2fc81d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6bd/5446266/a1cda88c2923/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6bd/5446266/aa5aaea04cac/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6bd/5446266/1b0453278b90/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6bd/5446266/bff9590ff0a1/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6bd/5446266/0f3abd9ae6f7/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6bd/5446266/4c88a557b3c4/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6bd/5446266/6b50ea2fc81d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6bd/5446266/a1cda88c2923/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6bd/5446266/aa5aaea04cac/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6bd/5446266/1b0453278b90/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6bd/5446266/bff9590ff0a1/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6bd/5446266/0f3abd9ae6f7/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6bd/5446266/4c88a557b3c4/gr7.jpg

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