Major Robert J, Poss Kenneth D
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710 USA.
Drug Discov Today Dis Models. 2007;4(4):219-225. doi: 10.1016/j.ddmod.2007.09.002.
Heart disease remains the leading cause of mortality throughout the world. Mammals have an extremely limited capacity to repair lost or damaged heart tissue, thus encouraging biologists to seek out models for heart regeneration. Zebrafish exhibit a robust regenerative capacity in a variety of tissues including the fin, spinal cord, retina, and heart, making it the sole regenerative vertebrate organism currently amenable to genetic manipulation. Future studies will utilize functional approaches to tease apart zebrafish heart regeneration in hopes of unlocking our own regenerative potential.
心脏病仍然是全球主要的死亡原因。哺乳动物修复受损心脏组织的能力极其有限，这促使生物学家寻找心脏再生的模型。斑马鱼在包括鳍、脊髓、视网膜和心脏在内的多种组织中表现出强大的再生能力，使其成为目前唯一适合进行基因操作的可再生脊椎动物。未来的研究将采用功能性方法来剖析斑马鱼的心脏再生机制，以期挖掘出我们自身的再生潜力。
