斑马鱼心脏再生作为心脏组织修复的模型
Zebrafish Heart Regeneration as a Model for Cardiac Tissue Repair.
作者信息
Major Robert J, Poss Kenneth D
机构信息
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710 USA.
出版信息
Drug Discov Today Dis Models. 2007;4(4):219-225. doi: 10.1016/j.ddmod.2007.09.002.
Abstract
Heart disease remains the leading cause of mortality throughout the world. Mammals have an extremely limited capacity to repair lost or damaged heart tissue, thus encouraging biologists to seek out models for heart regeneration. Zebrafish exhibit a robust regenerative capacity in a variety of tissues including the fin, spinal cord, retina, and heart, making it the sole regenerative vertebrate organism currently amenable to genetic manipulation. Future studies will utilize functional approaches to tease apart zebrafish heart regeneration in hopes of unlocking our own regenerative potential.
摘要
心脏病仍然是全球主要的死亡原因。哺乳动物修复受损心脏组织的能力极其有限，这促使生物学家寻找心脏再生的模型。斑马鱼在包括鳍、脊髓、视网膜和心脏在内的多种组织中表现出强大的再生能力，使其成为目前唯一适合进行基因操作的可再生脊椎动物。未来的研究将采用功能性方法来剖析斑马鱼的心脏再生机制，以期挖掘出我们自身的再生潜力。
相似文献
1
Zebrafish Heart Regeneration as a Model for Cardiac Tissue Repair.斑马鱼心脏再生作为心脏组织修复的模型
Drug Discov Today Dis Models. 2007;4(4):219-225. doi: 10.1016/j.ddmod.2007.09.002.
2
The zebrafish as a model for complex tissue regeneration.斑马鱼作为复杂组织再生的模型。
Trends Genet. 2013 Nov;29(11):611-20. doi: 10.1016/j.tig.2013.07.003. Epub 2013 Aug 6.
3
[Progress and application of zebrafish in regenerative medicine].斑马鱼在再生医学中的研究进展与应用
Yi Chuan. 2013 Jul;35(7):856-66. doi: 10.3724/sp.j.1005.2013.00856.
4
Zebrafish Regulatory T Cells Mediate Organ-Specific Regenerative Programs.斑马鱼调节性 T 细胞介导器官特异性再生程序。
Dev Cell. 2017 Dec 18;43(6):659-672.e5. doi: 10.1016/j.devcel.2017.11.010.
5
Mechanical Ablation of Larval Zebrafish Spinal Cord.机械消融斑马鱼脊髓幼虫。
Methods Mol Biol. 2024;2746:47-56. doi: 10.1007/978-1-0716-3585-8_3.
6
Advances in understanding the mechanism of zebrafish heart regeneration.斑马鱼心脏再生机制研究进展。
Stem Cell Res. 2014 Nov;13(3 Pt B):542-55. doi: 10.1016/j.scr.2014.07.003. Epub 2014 Jul 19.
7
Turning back the cardiac regenerative clock: lessons from the neonate.逆转心脏再生时钟：来自新生儿的启示。
Trends Cardiovasc Med. 2012 Jul;22(5):128-33. doi: 10.1016/j.tcm.2012.07.008. Epub 2012 Aug 14.
8
Using zebrafish as the model organism to understand organ regeneration.利用斑马鱼作为模式生物来理解器官再生。
Sci China Life Sci. 2015 Apr;58(4):343-51. doi: 10.1007/s11427-015-4838-z. Epub 2015 Apr 11.
9
Decoding the proregenerative competence of regulatory T cells through complex tissue regeneration in zebrafish.通过斑马鱼复杂的组织再生来解码调节性 T 细胞的再生能力。
Clin Exp Immunol. 2021 Dec;206(3):346-353. doi: 10.1111/cei.13661. Epub 2021 Oct 14.
10
Decellularized zebrafish cardiac extracellular matrix induces mammalian heart regeneration.脱细胞斑马鱼心脏细胞外基质诱导哺乳动物心脏再生。
Sci Adv. 2016 Nov 18;2(11):e1600844. doi: 10.1126/sciadv.1600844. eCollection 2016 Nov.
引用本文的文献
1
Cardiac macrophage: Insights from murine models to translational potential for human studies.心脏巨噬细胞：从小鼠模型到人类研究转化潜力的见解。
J Mol Cell Cardiol. 2025 Jul;204:17-31. doi: 10.1016/j.yjmcc.2025.05.001. Epub 2025 May 10.
2
Cauterization of the root of the left coronary artery as a straightforward, large and reproducible ischemic injury model in neonatal mice.以左冠状动脉根部为靶点的灼烧法构建新生鼠简单、大量且可重现的心肌缺血损伤模型。
Lab Anim (NY). 2024 Nov;53(11):308-326. doi: 10.1038/s41684-024-01443-x. Epub 2024 Oct 22.
3
Exploring the Function of Epicardial Cells Beyond the Surface.探索心外膜细胞的表面下功能。
Circ Res. 2024 Jul 5;135(2):353-371. doi: 10.1161/CIRCRESAHA.124.321567. Epub 2024 Jul 4.
4
Technologies to Study Genetics and Molecular Pathways.研究遗传学和分子途径的技术。
Adv Exp Med Biol. 2024;1441:435-458. doi: 10.1007/978-3-031-44087-8_22.
5
Neural Crest.神经嵴。
Adv Exp Med Biol. 2024;1441:125-143. doi: 10.1007/978-3-031-44087-8_6.
6
Platelet-Rich Plasma for Heart Cell Regeneration Post-myocardial Infarction: A Propitious Therapeutic Approach.富含血小板血浆用于心肌梗死后心脏细胞再生：一种有前景的治疗方法。
Cureus. 2024 Jan 9;16(1):e51951. doi: 10.7759/cureus.51951. eCollection 2024 Jan.
7
Unmasking the Confounder: The Inherent Physiologic Variability of Swine During an Automated Experimental Model of Ischemia-Reperfusion Injury.揭示混杂因素：在自动缺血再灌注损伤实验模型中猪的固有生理变异性。
Am Surg. 2022 Aug;88(8):1838-1844. doi: 10.1177/00031348221084967. Epub 2022 Apr 7.
8
Using Zebrafish as a Disease Model to Study Fibrotic Disease.利用斑马鱼作为疾病模型来研究纤维性疾病。
Int J Mol Sci. 2021 Jun 15;22(12):6404. doi: 10.3390/ijms22126404.
9
Maternal control of visceral asymmetry evolution in Astyanax cavefish.母体控制洞穴鮰鱼内脏不对称演化。
Sci Rep. 2021 May 13;11(1):10312. doi: 10.1038/s41598-021-89702-6.
10
Unlocking mammalian regeneration through hypoxia inducible factor one alpha signaling.通过缺氧诱导因子-1α信号通路开启哺乳动物再生能力。
Biomaterials. 2021 Feb;269:120646. doi: 10.1016/j.biomaterials.2020.120646. Epub 2021 Jan 9.
本文引用的文献
1
Biology of Isl1+ cardiac progenitor cells in development and disease.Isl1+心脏祖细胞在发育和疾病中的生物学特性
Cell Mol Life Sci. 2007 Mar;64(6):674-82. doi: 10.1007/s00018-007-6520-5.
2
Tail regeneration in the Xenopus tadpole.非洲爪蟾蝌蚪的尾部再生
Dev Growth Differ. 2007 Feb;49(2):155-61. doi: 10.1111/j.1440-169X.2007.00912.x.
3
Brain regeneration in anuran amphibians.无尾两栖动物的脑再生
Dev Growth Differ. 2007 Feb;49(2):121-9. doi: 10.1111/j.1440-169X.2007.00914.x.
4
Conditional targeted cell ablation in zebrafish: a new tool for regeneration studies.斑马鱼中的条件性靶向细胞消融：再生研究的新工具。
Dev Dyn. 2007 Apr;236(4):1025-35. doi: 10.1002/dvdy.21100.
5
Progenitor cells for cardiac repair.用于心脏修复的祖细胞。
Semin Cell Dev Biol. 2007 Feb;18(1):153-60. doi: 10.1016/j.semcdb.2006.12.009. Epub 2006 Dec 21.
6
Epithelial stem cells: turning over new leaves.上皮干细胞：焕新如初。
Cell. 2007 Feb 9;128(3):445-58. doi: 10.1016/j.cell.2007.01.014.
7
Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells.胰岛1在不同的心血管谱系中表达，包括起搏细胞和冠状血管细胞。
Dev Biol. 2007 Apr 1;304(1):286-96. doi: 10.1016/j.ydbio.2006.12.048. Epub 2006 Dec 29.
8
Limb regeneration in amphibians: immunological considerations.两栖动物的肢体再生：免疫学考量
ScientificWorldJournal. 2006 Feb 26;6 Suppl 1:1-11. doi: 10.1100/tsw.2006.323.
9
The role of stem cells in physiology, pathophysiology, and therapy of the liver.干细胞在肝脏生理学、病理生理学及治疗中的作用。
Stem Cell Rev. 2006;2(1):51-8. doi: 10.1007/s12015-006-0009-8.
10
Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization.胸腺素β4可诱导成年心外膜祖细胞动员和新生血管形成。
Nature. 2007 Jan 11;445(7124):177-82. doi: 10.1038/nature05383. Epub 2006 Nov 15.
Zotero 插件