Roggia Simone Mariotto, Colares Nádia Tenório
Doctor, adjunct professor of the Speech Therapy course, UNIVALI - SC.
Student of Speech Therapy, UNIVALI - SC; science initiation scholarship. Universidade do Vale do Itajaí.
Braz J Otorhinolaryngol. 2008 Sep-Oct;74(5):705-711. doi: 10.1016/S1808-8694(15)31380-X.
Mismatch Negativity (MMN) is a long-latency auditory evoked potential that provides an objective index of discrimination skills and auditory sensorial memory. It may, therefore, be used as an electrophysiological evaluation of central auditory processing.
To study MMN in patients with Central Auditory Processing Disorder - CAPD.
A prospective clinical study.
Eight individuals with CAPD, aged between nine and 14 years, were evaluated; there was also a control group. MMN was elicited for tone stimuli (tone bursts), differing in terms of frequency (MMNf - standard stimulus: 750 Hz and deviant stimulus: 1,000 Hz ), as well as duration (MMNd - standard stimulus: 100 ms and deviant stimulus: 50 ms; at 1,000 Hz).
The presence of MMNf and of MMNd was statistically demonstrated in both groups. No significant statistical differences, however, were observed between MMNf and MMNd latencies and amplitude values in the two groups. Also, no significant statistical differences were observed between the MMNf and the MMNd among the groups.
The CAPD individuals that were evaluated showed no changes in MMNf or MMNd.
失匹配负波（MMN）是一种长潜伏期听觉诱发电位，可提供辨别技能和听觉感觉记忆的客观指标。因此，它可用作中枢听觉处理的电生理评估。
研究中枢听觉处理障碍（CAPD）患者的MMN。
一项前瞻性临床研究。
对8名年龄在9至14岁之间的CAPD患者进行评估；同时设立一个对照组。针对频率不同（MMNf - 标准刺激：750赫兹，偏差刺激：1000赫兹）以及持续时间不同（MMNd - 标准刺激：100毫秒，偏差刺激：50毫秒；在1000赫兹时）的纯音刺激（短纯音）诱发MMN。
两组均在统计学上证实存在MMNf和MMNd。然而，两组之间MMNf和MMNd的潜伏期及波幅数值未观察到显著统计学差异。此外，两组之间的MMNf和MMNd也未观察到显著统计学差异。
接受评估的CAPD患者在MMNf或MMNd方面未显示出变化。
