Korting H C, Schöllmann C
Klinik und Poliklinik für Dermatologie und Allergologie, Klinikum der Ludwig-Maximilians-Universität München, Frauenlobstrasse 9-11, 80337, München.
Hautarzt. 2009 Jan;60(1):42-7. doi: 10.1007/s00105-008-1669-x.
Topical antibiotics, especially clindamycin, are well-accepted in the treatment of mild to moderate acne. Combinations of clindamycin and other agents such as benzoyl peroxide, retinoids or zinc, are possibly superior to clindamycin monotherapy regarding efficacy and tolerability with the combination 1% clindamycin/5% benzoyl peroxide being particularly well-supported by evidence. Moreover, a recent study has shown that patients themselves prefer a complex of zinc acetate/clindamycin phosphate.
外用抗生素,尤其是克林霉素,在治疗轻至中度痤疮方面被广泛接受。克林霉素与其他药物如过氧化苯甲酰、维甲酸或锌的联合使用,在疗效和耐受性方面可能优于克林霉素单药治疗,1%克林霉素/5%过氧化苯甲酰的联合使用有充分的证据支持。此外,最近的一项研究表明,患者自己更喜欢醋酸锌/磷酸克林霉素复合物。