Guerrero-Romero F, Rodríguez-Morán M
Research Group on Diabetes and Chronic Illnesses, Medical Research Unit in Clinical Epidemiology, Mexican Social Security Institute, Durango, Mexico.
Acta Diabetol. 2002 Dec;39(4):209-13. doi: 10.1007/s005920200036.
Low serum magnesium levels are related to diabetes mellitus (DM) and high blood pressure (HBP), but as far as we know, there are no previous reports that analyzed the serum magnesium concentration in individuals with metabolic syndrome (MS). We performed a cross-sectional population-based study to compare 192 individuals with MS and 384 disorder-free control subjects, matched by age and gender. Magnesium supplementation treatment and conditions likely to provoke hypomagnesemia, including previous diagnosis of diabetes mellitus (DM) and/or high blood pressure (HBP), were exclusion criteria. In this regard, only incident cases of DM and HBP were included. MS was defined by the presence at least of two of the following features: hyperglycemia (> or =7.0 mmol/l); HBP (> or =160/90 mmHg); dyslipidemia (fasting triglycerides > or =1.7 mmol/l and/or HDL-cholesterol <1.0 mmol/l); and obesity (body mass index > or =30 kg/m(2) and/or waist-to-hip ratio > or =0.85 in women or > or =0.9 in men). Low serum magnesium levels were identified in 126 (65.6%) and 19 (4.9%) individuals with and without MS, p<0.00001. The mean serum magnesium level among subjects with MS was 1.8+/-0.3 mg/dl, and among control subjects 2.2+/-0.2 mg/dl, p<0.00001. There was a strong independent relationship between low serum magnesium levels and MS (odds ratio (OR)=6.8, CI(95%) 4.2-10.9). Among the components of MS, dyslipidemia (OR 2.8, CI(95%) 1.3-2.9) and HBP (OR 1.9, CI(95%) 1.4-2.8) were strongly related to low serum magnesium levels. This study reveals a strong relationship between decreased serum magnesium and MS.
血清镁水平低与糖尿病（DM）和高血压（HBP）相关，但据我们所知，此前尚无分析代谢综合征（MS）患者血清镁浓度的报告。我们进行了一项基于人群的横断面研究，比较了192例MS患者和384例无疾病对照者，两组在年龄和性别上相匹配。排除标准包括镁补充治疗以及可能引发低镁血症的情况，包括既往诊断为糖尿病（DM）和/或高血压（HBP）。在这方面，仅纳入糖尿病和高血压的新发病例。MS的定义为至少存在以下两种特征：高血糖（≥7.0 mmol/l）；高血压（≥160/90 mmHg）；血脂异常（空腹甘油三酯≥1.7 mmol/l和/或高密度脂蛋白胆固醇<1.0 mmol/l）；以及肥胖（体重指数≥30 kg/m²且女性腰臀比≥0.85或男性≥0.9）。126例（65.6%）有MS和19例（4.9%）无MS的个体血清镁水平低，p<0.00001。MS患者的平均血清镁水平为1.8±0.3 mg/dl，对照者为2.2±0.2 mg/dl，p<0.00001。血清镁水平低与MS之间存在强独立关系（优势比（OR）=6.8，95%置信区间（CI）4.2 - 10.9）。在MS的组成成分中，血脂异常（OR 2.8，95%CI 1.3 - 2.9）和高血压（OR 1.9，95%CI 1.4 - 2.8）与血清镁水平低密切相关。本研究揭示了血清镁降低与MS之间的强关系。
