Palo Jukka U, Hedman Minttu, Ulmanen Ismo, Lukka Matti, Sajantila Antti
Department of Forensic Medicine, P.O. Box 40, University of Helsinki, FIN-00014 Helsinki, Finland.
Forensic Sci Int Genet. 2007 Jun;1(2):120-4. doi: 10.1016/j.fsigen.2007.02.001. Epub 2007 Mar 9.
Among the Finns, the levels of autosomal STR and mtDNA variation have been reported to be relatively high and evenly distributed throughout the country. In contrast, the Y-STR variation is markedly lower than observed in most other European populations, showing notable geographical substructure within Finland. There are striking interregional differences--the western, middle and eastern parts of Finland segregate clearly, with phiST values comparable to the highest divergences among European populations. The low Y-STR diversity reduces the discriminative power of Y-chromosomal markers among Finns, and, furthermore, the geographical substructure complicates the assessment of profile probabilities in forensic settings. Here, the Y-STR diversity pattern in Finland is for the first time evaluated from the forensic viewpoint.
据报道，在芬兰人中，常染色体短串联重复序列（autosomal STR）和线粒体DNA（mtDNA）的变异水平相对较高，且在全国分布均匀。相比之下，Y染色体短串联重复序列（Y-STR）的变异明显低于大多数其他欧洲人群，在芬兰境内呈现出显著的地理亚结构。地区间存在显著差异——芬兰的西部、中部和东部明显分开，PhiST值与欧洲人群中最高的差异相当。Y-STR多样性较低降低了Y染色体标记在芬兰人中的鉴别能力，此外，地理亚结构使法医环境中轮廓概率的评估变得复杂。在此，首次从法医角度评估了芬兰的Y-STR多样性模式。
