Stickler D, Dolman J, Rolfe S, Chawla J
School of Pure and Applied Biology, University of Wales College of Cardiff, UK.
Eur J Clin Microbiol Infect Dis. 1991 May;10(5):410-5. doi: 10.1007/BF01968020.
The activity of chlorhexidine, mandelic acid and a mandelic/lactic mixture were tested against biofilms of four species of gram-negative nosocomial organisms that commonly infect the catheterized urinary tract. Cells growing on silicone discs were exposed to concentrations of agents used in bladder instillation. Citrobacter diversus biofilms proved to be sensitive to all three agents. Pseudomonas aeruginosa, Proteus mirabilis and Klebsiella pneumoniae all survived well in chlorhexidine but their viability was significantly reduced by the mandelic acid formulations. These results suggest that bladder instillations of mandelic acid or mandelic/lactic acids would be more effective than chlorhexidine in eliminating biofilms from catheter surfaces.
测试了洗必泰、扁桃酸以及扁桃酸/乳酸混合物对四种常见于导尿管相关尿路感染的革兰氏阴性医院感染菌生物膜的活性。在硅胶圆盘上生长的细胞暴露于膀胱灌注中所使用的药剂浓度下。奇异柠檬酸杆菌生物膜被证明对所有三种药剂均敏感。铜绿假单胞菌、奇异变形杆菌和肺炎克雷伯菌在洗必泰中均存活良好，但扁桃酸制剂显著降低了它们的活力。这些结果表明，膀胱灌注扁桃酸或扁桃酸/乳酸比洗必泰在消除导尿管表面生物膜方面更有效。
