Stickler D J, Plant S, Bunni N H, Chawla J C
Paraplegia. 1981;19(6):325-33. doi: 10.1038/sc.1981.63.
A comparison has been made of the activity of three antiseptics that are used as bladder irrigants in the treatment of urinary tract infection in catheterised patients. At the concentrations and exposure times used for bladder irrigation, phenoxyethanol (2:4% v/v) proved to be highly bactericidal against urine-grown cells of all the common urinary pathogens tested. Chlorhexidine (200 microgram/ml) was active against Escherichia coli and produced significant reductions in the viability of Klebsiella pneumoniae, Proteus mirabilis and Pseudomonas aeruginosa but failed to eradicate Providencia stuartii. Exposure to noxythiolin (2.5% v/v) for 20 min had little effect in any of the bacteria, even though all strains tested had been recorded as noxythiolin-sensitive by conventional plate sensitivity tests. Contact with noxythiolin for periods of at least 1-2 hrs was necessary before extensive bactericidal activity was detected. These results provide an explanation of the poor clinical performance of noxythiolin that we have observed.
对三种用作膀胱冲洗剂以治疗导尿患者尿路感染的防腐剂活性进行了比较。在用于膀胱冲洗的浓度和暴露时间下，苯氧乙醇（2:4% v/v）对所有测试的常见尿路病原体的尿液培养细胞具有高度杀菌作用。洗必泰（200微克/毫升）对大肠杆菌有活性，并能显著降低肺炎克雷伯菌、奇异变形杆菌和铜绿假单胞菌的活力，但未能根除斯氏普罗威登斯菌。即使通过传统平板敏感性试验记录所有测试菌株对硝噻唑啉敏感，但暴露于硝噻唑啉（2.5% v/v）20分钟对任何细菌的影响都很小。在检测到广泛的杀菌活性之前，需要与硝噻唑啉接触至少1-2小时。这些结果解释了我们观察到的硝噻唑啉临床效果不佳的原因。
