Blumenthal Jacob, Behar Leah, Elliott Evan, Ginzburg Irith
Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, Israel.
FEBS Lett. 2009 Jan 5;583(1):197-201. doi: 10.1016/j.febslet.2008.12.002. Epub 2008 Dec 10.
Decapping protein 1a (Dcp1a) is found in P-bodies and functions in mRNA cap removal prior to its degradation. The function and binding partners of Dcp1a have been thoroughly studied, however its expression pattern is still unclear. In this study we have monitored Dcp1a expression along brain development, neuronal differentiation and during cellular stress. We found that Dcp1a is hyperphosphorylated under these physiological conditions. We followed our observations and identified the specific amino acid residues that are phosphorylated. These findings suggest a novel post-translational modification that may influence the function of Dcp1a in response to various physiological cues.
去帽蛋白1a（Dcp1a）存在于P小体中，在mRNA降解之前发挥去除mRNA帽的作用。Dcp1a的功能和结合伙伴已得到充分研究，但其表达模式仍不清楚。在本研究中，我们监测了Dcp1a在大脑发育、神经元分化以及细胞应激过程中的表达情况。我们发现，在这些生理条件下，Dcp1a发生了过度磷酸化。我们基于观察结果，鉴定出了发生磷酸化的特定氨基酸残基。这些发现提示了一种新的翻译后修饰，它可能会影响Dcp1a在响应各种生理信号时的功能。
