Iyer K S, Mahale S D, Hurkadli K S, Sheth A R
Indian J Exp Biol. 1989 Jan;27(1):10-3.
Synthesis and biological profile of a decapeptide analogue, [Tyr85, Cys(Acm)87]85-94 of human seminal plasma inhibin (HSPI) are described. The peptide suppressed the circulatory levels of follicle stimulating hormone (FSH) in adult male rats. No change in the levels of luteinizing hormone (LH) and prolactin (Prl) was observed. Whereas the peptide suppressed the release of both FSH and LH in vitro. This decapeptide is the smallest peptide reported so far to have FSH suppressing activity.
本文描述了人精浆抑制素（HSPI）的十肽类似物[Tyr85, Cys(Acm)87]85 - 94的合成及生物学特性。该肽可抑制成年雄性大鼠体内促卵泡激素（FSH）的循环水平。促黄体生成素（LH）和催乳素（Prl）水平未观察到变化。而该肽在体外可抑制FSH和LH的释放。这种十肽是迄今为止报道的具有FSH抑制活性的最小肽。
