Ananthakrishnan Ashwin N, McGinley Emily L, Saeian Kia
Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.
Clin Gastroenterol Hepatol. 2009 Mar;7(3):296-302e1. doi: 10.1016/j.cgh.2008.08.013. Epub 2008 Aug 19.
BACKGROUND & AIMS: Previous studies have identified a weekend effect in outcomes of patients with various medical conditions suggesting worse outcomes for weekend admissions. The aim of our study was to analyze if weekend admissions for upper gastrointestinal hemorrhage (UGIH) have higher mortality and longer hospital stay compared with those admitted on weekdays, and to examine if this effect differs by hospital teaching status.
This was a cross-sectional study using the Nationwide Inpatient Sample 2004. A total of 28,820 discharges with acute variceal hemorrhage (AVH) and 391,119 discharges with acute nonvariceal UGIH (NVUGIH) were identified through appropriate International Classification of Diseases, ninth edition codes. Admissions were considered to be weekend admissions if they were admitted between midnight on Friday through midnight on Sunday. In-hospital mortality, frequency, and timing of endoscopy were measured.
On multivariate analysis, NVUGIH patients admitted on weekends had higher adjusted in-hospital mortality (odds ratio [OR], 1.21; 95% confidence interval [CI], 1.09-1.35) and were less likely to undergo early endoscopy within 1 day of hospitalization (OR, 0.64; 95% CI, 0.61-0.68). Weekend admission was not predictive of in-hospital mortality in patients with AVH (OR, 0.94; 95% CI, 0.75-1.18), but was associated with lower likelihood of early endoscopy in nonteaching hospitals (OR, 0.65; 95% CI, 0.51-0.82). Early endoscopy was associated with significantly shorter hospital stays (NVUGIH, -1.08 days; AVH, -2.35 days) and lower hospitalization charges (NVUGIH, -$1958; AVH, -$8870).
Patients with NVUGIH admitted on the weekend had higher mortality and lower rates of early endoscopy. Patient with AVH admitted to nonteaching hospitals also had lower utilization of early endoscopy, but no difference in survival. There is a need for research into identifying the reasons for the weekend effect.
既往研究已证实多种疾病患者的治疗结局存在周末效应,提示周末入院患者的结局较差。本研究旨在分析上消化道出血(UGIH)患者周末入院与工作日入院相比是否具有更高的死亡率和更长的住院时间,并探讨这种效应是否因医院教学状况而异。
这是一项使用2004年全国住院患者样本的横断面研究。通过适当的国际疾病分类第九版编码,共识别出28820例急性静脉曲张出血(AVH)出院病例和391119例急性非静脉曲张性UGIH(NVUGIH)出院病例。如果患者在周五午夜至周日午夜之间入院,则被视为周末入院。测量住院死亡率、内镜检查的频率和时间。
多因素分析显示,周末入院的NVUGIH患者调整后的住院死亡率较高(比值比[OR],1.21;95%置信区间[CI],1.09 - 1.35),且在住院1天内接受早期内镜检查的可能性较小(OR,0.64;95%CI,0.61 - 0.68)。周末入院并非AVH患者住院死亡率的预测因素(OR,0.94;95%CI,0.75 - 1.18),但与非教学医院早期内镜检查的可能性较低相关(OR,0.65;95%CI,0.51 - 0.82)。早期内镜检查与显著缩短的住院时间相关(NVUGIH,-1.08天;AVH,-2.35天)以及较低的住院费用(NVUGIH,-1958美元;AVH,-8870美元)。
周末入院的NVUGIH患者死亡率较高且早期内镜检查率较低。非教学医院收治的AVH患者早期内镜检查的利用率也较低,但生存率无差异。有必要开展研究以确定周末效应的原因。