Howard Hughes Medical Institute, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Trans R Soc Trop Med Hyg. 2009 Apr;103 Suppl 1(Suppl 1):S11-4. doi: 10.1016/j.trstmh.2008.11.002. Epub 2008 Dec 12.
Molecular epidemiological investigations have uncovered the patterns of emergence and global spread of Plasmodium falciparum resistance to chloroquine and sulfadoxine-pyrimethamine. Malaria parasites highly resistant to chloroquine and pyrimethamine spread from Asian origins to Africa, at great cost to human health and life. If artemisinin-resistant falciparum malaria follows the same pattern, renewed efforts to eliminate and eradicate malaria will be gravely threatened. This paper, adapted from a talk given in honour of Professor Malcolm Molyneux in Liverpool in September 2008, reviews the rise and fall of clinically important forms of drug-resistant falciparum malaria and considers how lessons learned from studying the evolution of drug-resistant malaria can be applied to efforts to prevent and deter resistance.
分子流行病学调查揭示了疟原虫对氯喹和磺胺多辛-乙胺嘧啶耐药性的出现和全球传播模式。对氯喹和乙胺嘧啶高度耐药的疟原虫从亚洲起源传播到非洲，给人类健康和生命带来了巨大的代价。如果青蒿素耐药性恶性疟按照同样的模式发展，消除和根除疟疾的努力将受到严重威胁。本文改编自 2008 年 9 月在利物浦为纪念马尔科姆·莫利纽克斯教授而作的演讲，回顾了临床上重要的耐药性恶性疟的兴衰，并探讨了从研究耐药性疟疾的演变中吸取的经验教训如何应用于预防和遏制耐药性的努力。
