耐药性疟疾的演变。
The evolution of drug-resistant malaria.
机构信息
Howard Hughes Medical Institute, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
出版信息
Trans R Soc Trop Med Hyg. 2009 Apr;103 Suppl 1(Suppl 1):S11-4. doi: 10.1016/j.trstmh.2008.11.002. Epub 2008 Dec 12.
Abstract
Molecular epidemiological investigations have uncovered the patterns of emergence and global spread of Plasmodium falciparum resistance to chloroquine and sulfadoxine-pyrimethamine. Malaria parasites highly resistant to chloroquine and pyrimethamine spread from Asian origins to Africa, at great cost to human health and life. If artemisinin-resistant falciparum malaria follows the same pattern, renewed efforts to eliminate and eradicate malaria will be gravely threatened. This paper, adapted from a talk given in honour of Professor Malcolm Molyneux in Liverpool in September 2008, reviews the rise and fall of clinically important forms of drug-resistant falciparum malaria and considers how lessons learned from studying the evolution of drug-resistant malaria can be applied to efforts to prevent and deter resistance.
摘要
分子流行病学调查揭示了疟原虫对氯喹和磺胺多辛-乙胺嘧啶耐药性的出现和全球传播模式。对氯喹和乙胺嘧啶高度耐药的疟原虫从亚洲起源传播到非洲，给人类健康和生命带来了巨大的代价。如果青蒿素耐药性恶性疟按照同样的模式发展，消除和根除疟疾的努力将受到严重威胁。本文改编自 2008 年 9 月在利物浦为纪念马尔科姆·莫利纽克斯教授而作的演讲，回顾了临床上重要的耐药性恶性疟的兴衰，并探讨了从研究耐药性疟疾的演变中吸取的经验教训如何应用于预防和遏制耐药性的努力。
相似文献
1
The evolution of drug-resistant malaria.
Trans R Soc Trop Med Hyg. 2009 Apr;103 Suppl 1(Suppl 1):S11-4. doi: 10.1016/j.trstmh.2008.11.002. Epub 2008 Dec 12.
2
Molecular surveillance of Plasmodium falciparum drug resistance markers reveals partial recovery of chloroquine susceptibility but sustained sulfadoxine-pyrimethamine resistance at two sites of different malaria transmission intensities in Rwanda.
Acta Trop. 2016 Dec;164:329-336. doi: 10.1016/j.actatropica.2016.09.008. Epub 2016 Sep 17.
3
Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next?
Trends Parasitol. 2001 Dec;17(12):582-8. doi: 10.1016/s1471-4922(01)02085-2.
4
Detection of drug resistance markers for chloroquine and pyrimethamine-sulfadoxine in Jazan area, Saudi Arabia using PCR and restriction digestion.
J Egypt Soc Parasitol. 2007 Apr;37(1):17-30.
5
Molecular analysis of chloroquine and sulfadoxine-pyrimethamine resistance-associated alleles in Plasmodium falciparum isolates from Nicaragua.
Am J Trop Med Hyg. 2014 May;90(5):840-5. doi: 10.4269/ajtmh.13-0214. Epub 2014 Mar 10.
6
The differing impact of chloroquine and pyrimethamine/sulfadoxine upon the infectivity of malaria species to the mosquito vector.
Am J Trop Med Hyg. 1998 Feb;58(2):176-82. doi: 10.4269/ajtmh.1998.58.176.
7
Chloroquine and sulphadoxine-pyrimethamine sensitivity of Plasmodium falciparum parasites in a Brazilian endemic area.
Malar J. 2009 Jul 14;8:156. doi: 10.1186/1475-2875-8-156.
8
Efficacy of sulfadoxine-pyrimethamine in chloroquine resistant falciparum malaria in Bombay.
J Assoc Physicians India. 1996 Oct;44(10):683-5.
9
Mapping the spread of malaria drug resistance.
PLoS Med. 2009 Apr 14;6(4):e1000054. doi: 10.1371/journal.pmed.1000054.
10
Community pyrimethamine-sulfadoxine use and prevalence of resistant Plasmodium falciparum genotypes in Mali: a model for deterring resistance.
Am J Trop Med Hyg. 1996 Nov;55(5):467-71. doi: 10.4269/ajtmh.1996.55.467.
引用本文的文献
1
Prevalence and genetic diversity of polymorphisms in , and genes of in southern Côte d'Ivoire.
Malariaworld J. 2025 Jan 6;16:1. doi: 10.5281/zenodo.14604138. eCollection 2025.
2
Screening for antifolate and artemisinin resistance in dried-blood spots from three hospitals of Eritrea.
F1000Res. 2024 Jun 12;10:628. doi: 10.12688/f1000research.54195.3. eCollection 2021.
3
Efficacy of artemether-lumefantrine and dihydroartemisinin-piperaquine and prevalence of molecular markers of anti-malarial drug resistance in children in Togo in 2021.
Malar J. 2024 Apr 3;23(1):92. doi: 10.1186/s12936-024-04922-1.
4
Putative molecular markers of resistance to antimalarial drugs in malaria parasites from Ghana.
Front Epidemiol. 2024 Feb 15;4:1279835. doi: 10.3389/fepid.2024.1279835. eCollection 2024.
5
Increase of parasites carrying lumefantrine-tolerance molecular markers and lack of South East Asian artemisinin-resistance mutations in samples collected from 2013 to 2016 in Côte d'Ivoire.
J Parasit Dis. 2024 Mar;48(1):59-66. doi: 10.1007/s12639-023-01640-4. Epub 2024 Jan 12.
6
Progress towards malaria elimination in the Greater Mekong Subregion: perspectives from the World Health Organization.
Malar J. 2024 Mar 1;23(1):64. doi: 10.1186/s12936-024-04851-z.
7
Plasmodium falciparum drug resistance-associated mutations in isolates from children living in endemic areas of Burkina Faso.
Malar J. 2023 Jul 20;22(1):213. doi: 10.1186/s12936-023-04645-9.
8
How can the complex epidemiology of malaria in India impact its elimination?
Trends Parasitol. 2023 Jun;39(6):432-444. doi: 10.1016/j.pt.2023.03.006. Epub 2023 Apr 6.
9
Population Genomic Evidence of Adaptive Response during the Invasion History of Plasmodium falciparum in the Americas.
Mol Biol Evol. 2023 May 2;40(5). doi: 10.1093/molbev/msad082.
10
Distinct pattern and prevalence of dihydropteroate synthase gene mutations in children with sickle cell anaemia and haemoglobin AA in Benin City, Nigeria: the impact of HbAA.
Pan Afr Med J. 2022 Oct 13;43:80. doi: 10.11604/pamj.2022.43.80.34334. eCollection 2022.
本文引用的文献
1
Monitoring and deterring drug-resistant malaria in the era of combination therapy.
Am J Trop Med Hyg. 2007 Dec;77(6 Suppl):160-9.
2
World Antimalarial Resistance Network (WARN) III: molecular markers for drug resistant malaria.
Malar J. 2007 Sep 6;6:121. doi: 10.1186/1475-2875-6-121.
3
Pfmdr1 and in vivo resistance to artesunate-mefloquine in falciparum malaria on the Cambodian-Thai border.
Am J Trop Med Hyg. 2007 Apr;76(4):641-7.
4
Return of chloroquine antimalarial efficacy in Malawi.
N Engl J Med. 2006 Nov 9;355(19):1959-66. doi: 10.1056/NEJMoa062032.
5
P. falciparum dihydrofolate reductase and dihydropteroate synthase mutations: epidemiology and role in clinical resistance to antifolates.
Drug Resist Updat. 1998;1(6):389-96. doi: 10.1016/s1368-7646(98)80014-9.
6
Intercontinental spread of pyrimethamine-resistant malaria.
Science. 2004 Aug 20;305(5687):1124. doi: 10.1126/science.1098876.
7
Resistance of Plasmodium falciparum in Tanganyika to pyrimethamine administered at weekly intervals.
Trans R Soc Trop Med Hyg. 1957 Nov;51(6):505-13. doi: 10.1016/0035-9203(57)90039-1.
8
Reemergence of chloroquine-sensitive Plasmodium falciparum malaria after cessation of chloroquine use in Malawi.
J Infect Dis. 2003 Jun 15;187(12):1870-5. doi: 10.1086/375419. Epub 2003 May 21.
9
Origin and dissemination of Plasmodium falciparum drug-resistance mutations in South America.
J Infect Dis. 2002 Oct 1;186(7):999-1006. doi: 10.1086/342946. Epub 2002 Sep 9.
10
Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum.
Nature. 2002 Jul 18;418(6895):320-3. doi: 10.1038/nature00813.
Zotero 插件