丙型肝炎患者自我报告的聚乙二醇干扰素和利巴韦林治疗依从性。
Hepatitis C patients' self-reported adherence to treatment with pegylated interferon and ribavirin.
作者信息
Weiss J J, Bhatti L, Dieterich D T, Edlin B R, Fishbein D A, Goetz M B, Yu K, Wagner G J
机构信息
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA.
出版信息
Aliment Pharmacol Ther. 2008 Aug 1;28(3):289-93. doi: 10.1111/j.1365-2036.2008.03718.x.
Abstract
BACKGROUND
Prior research on adherence to hepatitis C treatment has documented rates of dose reductions and early treatment discontinuation, but little is known about patients' dose-taking adherence.
AIMS
To assess the prevalence of missed doses of pegylated interferon and ribavirin and examine the correlates of dose-taking adherence in clinic settings.
METHODS
One hundred and eighty patients on treatment for hepatitis C (23% coinfected with HIV) completed a cross-sectional survey at the site of their hepatitis C care.
RESULTS
Seven per cent of patients reported missing at least one injection of pegylated interferon in the last 4 weeks and 21% reported missing at least one dose of ribavirin in the last 7 days. Dose-taking adherence was not associated with HCV viral load.
CONCLUSIONS
Self-reported dose non-adherence to hepatitis C treatment occurs frequently. Further studies of dose non-adherence (assessed by method other than self-report) and its relationship to HCV virological outcome are warranted.
摘要
背景
先前关于丙型肝炎治疗依从性的研究记录了剂量减少和早期治疗中断的发生率，但对于患者的服药依从性知之甚少。
目的
评估聚乙二醇干扰素和利巴韦林漏服剂量的发生率，并在临床环境中检查服药依从性的相关因素。
方法
180例接受丙型肝炎治疗的患者（23%合并感染HIV）在其丙型肝炎治疗地点完成了一项横断面调查。
结果
7%的患者报告在过去4周内至少漏打了一针聚乙二醇干扰素，21%的患者报告在过去7天内至少漏服了一剂利巴韦林。服药依从性与丙型肝炎病毒载量无关。
结论
自我报告的丙型肝炎治疗剂量不依从情况频繁发生。有必要进一步研究剂量不依从（通过自我报告以外的方法评估）及其与丙型肝炎病毒学结果的关系。
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