Wagner Glenn, Chan Osilla Karen, Garnett Jeffrey, Ghosh-Dastidar Bonnie, Bhatti Laveeza, Goetz Matthew Bidwell, Witt Mallory
Health Unit, RAND Corporation, 1776 Main Street, P.O. Box 2138, Santa Monica, CA 90407, USA.
AIDS Res Treat. 2011;2011:903480. doi: 10.1155/2011/903480. Epub 2011 Oct 26.
Background. Hepatitis C (HCV) treatment efficacy among HIV patients is limited by poor treatment adherence and tolerance, but few studies have examined the psychosocial determinants of treatment adherence and outcomes. Methods. Chart abstracted and survey data were collected on 72 HIV patients who had received pegylated interferon and ribavirin to assess correlates of treatment adherence, completion, and sustained virologic response (SVR). Results. Nearly half (46%) the sample had active psychiatric problems and 13% had illicit drug use at treatment onset; 28% reported <100% treatment adherence, 38% did not complete treatment (mostly due to virologic nonresponse), and intent to treat SVR rate was 49%. Having a psychiatric diagnosis was associated with nonadherence, while better HCV adherence was associated with both treatment completion and SVR. Conclusions. Good mental health may be an indicator of HCV treatment adherence readiness, which is in turn associated with treatment completion and response, but further research is needed with new HCV treatments emerging.
背景。艾滋病毒患者的丙型肝炎（HCV）治疗效果受到治疗依从性差和耐受性的限制，但很少有研究探讨治疗依从性和结果的社会心理决定因素。方法。收集了72名接受聚乙二醇干扰素和利巴韦林治疗的艾滋病毒患者的病历摘要和调查数据，以评估治疗依从性、完成情况和持续病毒学应答（SVR）的相关因素。结果。近一半（46%）的样本在治疗开始时有活跃的精神问题，13%在治疗开始时有非法药物使用情况；28%报告治疗依从性<100%，38%未完成治疗（主要由于病毒学无应答），意向性治疗SVR率为49%。患有精神疾病诊断与不依从相关，而更好的HCV依从性与治疗完成和SVR均相关。结论。良好的心理健康可能是HCV治疗依从性准备情况的一个指标，而这反过来又与治疗完成和应答相关，但随着新的HCV治疗方法的出现，还需要进一步研究。
